PTPN3 Could Be a Therapeutic Target of Pancreatic Cancer

Hideya Ohnishi, Naoya Iwamoto, Keita Sakanashi, Satoko Koga, Yasuhiro Oyama, Kosuke Yanai, Katsuya Nakamura, Shuntaro Nagai, Akiko Fujimura, Kazunori Nakayama, Keigo Ozono, Akio Yamasaki

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Background/Aim: Recently, protein tyrosine phosphatase non-receptor type 3 (PTPN3) has gained attention. However, the role of PTPN3 in cancer has not been fully elucidated. In the present study, we analyzed the role of PTPN3 in pancreatic cancer and investigated whether PTPN3 could be a new therapeutic target for pancreatic cancer. Materials and Methods: Two pancreatic ductal adenocarcinoma (PDAC) cell lines were used as target cells. Cell proliferation was investigated using cell counting and a xenograft mouse model. Migration and invasion were analyzed using Transwell inserts. Activation-related signaling molecules were examined by western blotting. Results: PTPN3 contributes to the proliferation, migration, and invasion of PDAC cells in vitro. PTPN3 promotes tumor growth in a mouse xenograft model, an action mediated partially through the MAPK pathway. Conclusion: PTPN3 could be a new therapeutic target for pancreatic cancer.

本文言語英語
ページ(範囲)2869-2874
ページ数6
ジャーナルAnticancer research
42
6
DOI
出版ステータス出版済み - 6月 2022

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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