Purinergic signaling in microglia in the pathogenesis of neuropathic pain

Kazuhide Inoue

研究成果: Contribution to journalReview article査読

22 被引用数 (Scopus)

抄録

Nerve injury often causes debilitating chronic pain, referred to as neuropathic pain, which is refractory to currently available analgesics including morphine. Many reports indicate that activated spinal microglia evoke neuropathic pain. The P2X4 receptor (P2X4R), a subtype of ionotropic ATP receptors, is upregulated in spinal microglia after nerve injury by several factors, including CC chemokine receptor CCR2, the extracellular matrix protein fibronectin in the spinal cord, interferon regulatory factor 8 (IRF8) and IRF5. Inhibition of P2X4R function suppresses neuropathic pain, indicating that microglial P2X4R play a key role in evoking neuropathic pain.

本文言語英語
ページ(範囲)174-182
ページ数9
ジャーナルProceedings of the Japan Academy Series B: Physical and Biological Sciences
93
4
DOI
出版ステータス出版済み - 2017

All Science Journal Classification (ASJC) codes

  • 農業および生物科学(全般)
  • 物理学および天文学(全般)

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