Purinergic signaling in microglia in the pathogenesis of neuropathic pain

研究成果: ジャーナルへの寄稿評論記事

12 引用 (Scopus)

抄録

Nerve injury often causes debilitating chronic pain, referred to as neuropathic pain, which is refractory to currently available analgesics including morphine. Many reports indicate that activated spinal microglia evoke neuropathic pain. The P2X4 receptor (P2X4R), a subtype of ionotropic ATP receptors, is upregulated in spinal microglia after nerve injury by several factors, including CC chemokine receptor CCR2, the extracellular matrix protein fibronectin in the spinal cord, interferon regulatory factor 8 (IRF8) and IRF5. Inhibition of P2X4R function suppresses neuropathic pain, indicating that microglial P2X4R play a key role in evoking neuropathic pain.

元の言語英語
ページ(範囲)174-182
ページ数9
ジャーナルProceedings of the Japan Academy Series B: Physical and Biological Sciences
93
発行部数4
DOI
出版物ステータス出版済み - 1 1 2017

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pathogenesis
Purinergic P2X4 Receptors
pain
neuroglia
Microglia
Neuralgia
receptors
nerves
CCR Receptors
Purinergic P2 Receptors
nerve tissue
morphine
interferon
Extracellular Matrix Proteins
Wounds and Injuries
spinal cord
Fibronectins
Chronic Pain
Morphine
adenosine triphosphate

All Science Journal Classification (ASJC) codes

  • General

これを引用

Purinergic signaling in microglia in the pathogenesis of neuropathic pain. / Inoue, Kazuhide.

:: Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 巻 93, 番号 4, 01.01.2017, p. 174-182.

研究成果: ジャーナルへの寄稿評論記事

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