Purinergic systems in microglia

Kazuhide Inoue

研究成果: Contribution to journalReview article査読

99 被引用数 (Scopus)

抄録

Accumulating findings indicate that nucleotides play an important role in microglia through P2 purinoceptors. P2 purinoceptors are divided into two families, ionotropic receptors (P2X) and metabotropic receptors (P2Y). P2X receptors (7 types; P2X1 - P2X7) contain intrinsic pores that open by binding with ATP. P2Y receptors (8 types; P2Y 1, 2, 4, 6, 11, 12, 13 and 14) are activated by nucleotides and couple to intracellular second-messenger systems through heteromeric G-proteins. Nucleotides are released or leaked from non-excitable cells as well as neurons in physiological and pathophysiological conditions. Microglia express many types of P2 purinoceptors and are known as resident macrophages in the CNS. ATP and other nucleotides work as 'warning molecules' especially through activating microglia in pathophysiological conditions. Microglia play a key role in neuropathic pain, chemotaxis and phagocytosis through nucleotide-evoked activation of P2X4, P2Y12 and P2Y6 receptors, respectively. These findings indicate that extracellular nucleotides are important players in the central stage of microglial function.

本文言語英語
ページ(範囲)3074-3080
ページ数7
ジャーナルCellular and Molecular Life Sciences
65
19
DOI
出版ステータス出版済み - 10 1 2008

All Science Journal Classification (ASJC) codes

  • 細胞生物学
  • 分子生物学
  • 分子医療
  • 薬理学
  • 細胞および分子神経科学

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