Purinergic systems, neuropathic pain and the role of microglia

Kazuhide Inoue, Makoto Tsuda

研究成果: Contribution to journalReview article査読

53 被引用数 (Scopus)

抄録

We have learned various data on the role of purinoceptors (P2X4, P2X7, P2Y6 and P2Y12) expressed in spinal microglia and several factors that presumably activate microglia in neuropathic pain after peripheral nerve injury. Purinergic receptor-mediated spinal microglial functions make a critical contribution to pathologically enhanced pain processing in the dorsal horn. Microglial purinoceptors might be promising targets for treating neuropathic pain. A predicted therapeutic benefit of interfering with microglial purinergic receptors may be that normal pain sensitivity would be unaffected since expression or activity of most of these receptors are upregulated or enhanced predominantly in activated microglia in the spinal cord where damaged sensory fibers project.

本文言語英語
ページ(範囲)293-301
ページ数9
ジャーナルExperimental Neurology
234
2
DOI
出版ステータス出版済み - 4 2012

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

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