Pursaethosides A-E, triterpene saponins from Entada pursaetha

Azefack Léon Tapondjou, Tomofumi Miyamoto, Jean François Mirjolet, Nicolas Guilbaud, Marie Aleth Lacaille-Dubois

研究成果: Contribution to journalArticle査読

41 被引用数 (Scopus)

抄録

Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the η-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.

本文言語英語
ページ(範囲)1185-1190
ページ数6
ジャーナルJournal of Natural Products
68
8
DOI
出版ステータス出版済み - 8 1 2005

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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