Pyoderma gangrenosum with increased levels of serum cytokines

Kana Kozono, Takeshi Nakahara, Satoko Kikuchi, Eriko Itoh, Makiko Kido-Nakahara, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

A 66-year-old woman presented after an episode of accidental trauma with a painful ulcer on her scalp which rapidly enlarged in size, accompanied by central necrosis and undermining ulceration. The patient's past history was negative for underlying systemic disease, although she had had a similar post-traumatic intractable leg ulcer 3 years prior, which was unresponsive to surgical management but successfully treated with systemic steroids. A biopsied specimen from the scalp showed marked neutrophilic infiltrates in the dermis, compatible with a diagnosis of pyoderma gangrenosum (PG). The large ulcerative lesion responded very well to oral steroid therapy, showing rapid epithelialization. Serum levels of granulocyte colony-stimulating factor and interleukin-6 were significantly elevated prior to treatment, with decrease to normal levels after treatment. Serum tumor necrosis factor (TNF)-α and granulocyte macrophage colony-stimulating factor levels were within normal limits. The significance and pathogenic role of cytokine burst in PG is reviewed and discussed.

元の言語英語
ページ(範囲)1186-1188
ページ数3
ジャーナルJournal of Dermatology
42
発行部数12
DOI
出版物ステータス出版済み - 12 1 2015

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Pyoderma Gangrenosum
Cytokines
Scalp
Serum
Steroids
Leg Ulcer
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Dermis
Ulcer
Interleukin-6
Necrosis
Therapeutics
Tumor Necrosis Factor-alpha
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Pyoderma gangrenosum with increased levels of serum cytokines. / Kozono, Kana; Nakahara, Takeshi; Kikuchi, Satoko; Itoh, Eriko; Kido-Nakahara, Makiko; Furue, Masutaka.

:: Journal of Dermatology, 巻 42, 番号 12, 01.12.2015, p. 1186-1188.

研究成果: ジャーナルへの寄稿記事

Kozono, Kana ; Nakahara, Takeshi ; Kikuchi, Satoko ; Itoh, Eriko ; Kido-Nakahara, Makiko ; Furue, Masutaka. / Pyoderma gangrenosum with increased levels of serum cytokines. :: Journal of Dermatology. 2015 ; 巻 42, 番号 12. pp. 1186-1188.
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abstract = "A 66-year-old woman presented after an episode of accidental trauma with a painful ulcer on her scalp which rapidly enlarged in size, accompanied by central necrosis and undermining ulceration. The patient's past history was negative for underlying systemic disease, although she had had a similar post-traumatic intractable leg ulcer 3 years prior, which was unresponsive to surgical management but successfully treated with systemic steroids. A biopsied specimen from the scalp showed marked neutrophilic infiltrates in the dermis, compatible with a diagnosis of pyoderma gangrenosum (PG). The large ulcerative lesion responded very well to oral steroid therapy, showing rapid epithelialization. Serum levels of granulocyte colony-stimulating factor and interleukin-6 were significantly elevated prior to treatment, with decrease to normal levels after treatment. Serum tumor necrosis factor (TNF)-α and granulocyte macrophage colony-stimulating factor levels were within normal limits. The significance and pathogenic role of cytokine burst in PG is reviewed and discussed.",
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AU - Furue, Masutaka

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