Pyrimidine nucleotide synthesis is more extensive in poorly differentiated than in well‐differentiated human gastric carcinoma

Yoshihiko Maehara, Tetsuya Kusumoto, Yoshihisa Sakaguchi, Hiroki Kusumoto, Yuichiro Kido, Hideaki Anai, Keizo Sugimachi

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

In tissues obtained from patients undergoing gastrectomy the activities of 12 enzymes involved in pyrimidine nucleotide synthesis: cytidine triphosphate (CTP) synthetase, deoxycytidine monophosphate (dCMP) deaminase, thymidine monophosphate (dTMP) kinase, uridine (Urd), deoxycytidine (dCyd) and thymidine (dThd) kinases, Urd, deoxyuridine (dUrd) and dThd phosphoryiases, cytidine (Cyd) and dCyd deaminases, and DNA polymerase were examined in the eight‐well‐differentiated and 12 poorly differentiated gastric cancer tissues and the ten normal tissues. These cases were clinically advanced and serosal invasions were evident. Activities of these enzymes were higher in the poorly differentiated tissues than the well differentiated type and in the normal tissues. Significant differences were noted between the poorly differentiated and well‐differentiated types, in dTMP kinase (P < 0.02), dThd kinase (P < 0.05), dThd phosphorylase (P < 0.01), and DNA polymerase (P < 0.05). The authors' findings show that the level of pyrimidine nucleotide synthesis, in both de novo and salvage pathways, is higher in the poorly differentiated gastric cancer tissues than in the well‐differentiated type and suggest that antitumor drugs have an increased susceptibility in cases of poorly differentiated gastric carcinoma.

元の言語英語
ページ(範囲)96-101
ページ数6
ジャーナルCancer
63
発行部数1
DOI
出版物ステータス出版済み - 1 1 1989

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Pyrimidine Nucleotides
Stomach
dTMP kinase
Carcinoma
deoxycytidine deaminase
Thymidine Kinase
DNA-Directed DNA Polymerase
CTP synthetase
Stomach Neoplasms
DCMP Deaminase
Uridine Kinase
Deoxycytidine Kinase
Thymidine Phosphorylase
Cytidine Deaminase
Deoxyuridine
Uridine
Enzymes
Gastrectomy
Antineoplastic Agents
Thymidine

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Pyrimidine nucleotide synthesis is more extensive in poorly differentiated than in well‐differentiated human gastric carcinoma. / Maehara, Yoshihiko; Kusumoto, Tetsuya; Sakaguchi, Yoshihisa; Kusumoto, Hiroki; Kido, Yuichiro; Anai, Hideaki; Sugimachi, Keizo.

:: Cancer, 巻 63, 番号 1, 01.01.1989, p. 96-101.

研究成果: ジャーナルへの寄稿記事

Maehara, Yoshihiko ; Kusumoto, Tetsuya ; Sakaguchi, Yoshihisa ; Kusumoto, Hiroki ; Kido, Yuichiro ; Anai, Hideaki ; Sugimachi, Keizo. / Pyrimidine nucleotide synthesis is more extensive in poorly differentiated than in well‐differentiated human gastric carcinoma. :: Cancer. 1989 ; 巻 63, 番号 1. pp. 96-101.
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abstract = "In tissues obtained from patients undergoing gastrectomy the activities of 12 enzymes involved in pyrimidine nucleotide synthesis: cytidine triphosphate (CTP) synthetase, deoxycytidine monophosphate (dCMP) deaminase, thymidine monophosphate (dTMP) kinase, uridine (Urd), deoxycytidine (dCyd) and thymidine (dThd) kinases, Urd, deoxyuridine (dUrd) and dThd phosphoryiases, cytidine (Cyd) and dCyd deaminases, and DNA polymerase were examined in the eight‐well‐differentiated and 12 poorly differentiated gastric cancer tissues and the ten normal tissues. These cases were clinically advanced and serosal invasions were evident. Activities of these enzymes were higher in the poorly differentiated tissues than the well differentiated type and in the normal tissues. Significant differences were noted between the poorly differentiated and well‐differentiated types, in dTMP kinase (P < 0.02), dThd kinase (P < 0.05), dThd phosphorylase (P < 0.01), and DNA polymerase (P < 0.05). The authors' findings show that the level of pyrimidine nucleotide synthesis, in both de novo and salvage pathways, is higher in the poorly differentiated gastric cancer tissues than in the well‐differentiated type and suggest that antitumor drugs have an increased susceptibility in cases of poorly differentiated gastric carcinoma.",
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