Quantification of adverse effects of regular use of triazolam on clinical outcomes for older people with insomnia: A retrospective cohort study

Toshiki Maeda, Akira Babazono, Takumi Nishi, Midori Yasui

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Objective Older people are more likely to have insomnia. One of the most prescribed hypnotics in Japan is triazolam. Although some studies showed the possibility of adverse effects of triazolam in older people, there have been few studies investigating these effects in a clinical setting. The aim of this study was to determine whether patients who used triazolam regularly had increased risks of pneumonia, trauma, and pressure ulcers. Methods The research design was a retrospective cohort study using claim data. The subjects of the study were patients who were insured by Fukuoka Late Stage Elderly Healthcare Insurance. We defined patients who had received triazolam for 180 days or longer during fiscal year 2011 as the triazolam group, and those who had not received any hypnotics during the period as the non-triazolam group. Each patient in the triazolam group was then matched with a unique control from the non-triazolam group according to propensity score. Multivariate conditional logistic regression analyses were used to obtain adjusted odds ratios for pneumonia, trauma, and pressure ulcer in the triazolam group compared with the non-triazolam group. Results The number of patients in the triazolam and non-triazolam groups in the unmatched cohort was 13,015 and 411,610, respectively. Adjusted odds ratios show that the risks for pneumonia, trauma, and pressure ulcer in the matched cohort increased by approximately 40%, 30%, and slightly less than 30%, respectively (all statistically significant). Conclusions Regular use of triazolam is a risk factor for pneumonia, trauma, and pressure ulcer in older people.

本文言語英語
ページ(範囲)186-194
ページ数9
ジャーナルInternational Journal of Geriatric Psychiatry
31
2
DOI
出版ステータス出版済み - 2 1 2016

All Science Journal Classification (ASJC) codes

  • 老年医学
  • 精神医学および精神衛生

フィンガープリント

「Quantification of adverse effects of regular use of triazolam on clinical outcomes for older people with insomnia: A retrospective cohort study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル