Quantification of Maternal Microchimeric Cells in the Liver of Children With Biliary Atresia

Satoshi Tamaoka, Akinari Fukuda, Yuko Katoh-Fukui, Atsushi Hattori, Hajime Uchida, Seiichi Shimizu, Yusuke Yanagi, Sami B. Kanaan, Seisuke Sakamoto, Mureo Kasahara, Takako Yoshioka, Maki Fukami

研究成果: ジャーナルへの寄稿学術誌査読

抄録

ABSTRACT: Biliary atresia (BA) is a rare disorder of unknown etiology. There is a debate as to whether maternal microchimerism plays a significant role in the development of BA or in graft tolerance after liver transplantation. Here, we performed quantitative-PCR-based assays for liver tissues of children with BA and other diseases. Maternal cells were detected in 4/13 and 1/3 of the BA and control groups, respectively. The estimated number of maternal cells ranged between 0 and 34.7 per 106 total cells. The frequency and severity of maternal microchimerism were similar between the BA and control groups, and between patients with and without acute rejection of maternal grafts. These results highlight the high frequency of maternal microchimerism in the liver. This study provides no evidence for roles of microchimerism in the etiology of BA or in graft tolerance. Thus, the biological consequences of maternal microchimerism need to be clarified in future studies.

本文言語英語
ページ(範囲)e83-e86
ジャーナルJournal of pediatric gastroenterology and nutrition
74
4
DOI
出版ステータス出版済み - 4月 1 2022
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 消化器病学

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