TY - JOUR
T1 - Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model
AU - Katoh, Chietsugu
AU - Yoshinaga, Keiichiro
AU - Klein, Ran
AU - Kasai, Katsuhiko
AU - Tomiyama, Yuuki
AU - Manabe, Osamu
AU - Naya, Masanao
AU - Sakakibara, Mamoru
AU - Tsutsui, Hiroyuki
AU - DeKemp, Robert A.
AU - Tamaki, Nagara
PY - 2012/8
Y1 - 2012/8
N2 - Purpose. Myocardial blood flow (MBF) estimation with 82Rubidium (82Rb) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted leastsquares fitting. Methods. Fourteen volunteers underwent imaging with both 3-dimensional (3D) 82Rb and 15O-water PET at rest and during pharmacological stress. Whole left ventricular (LV) 82Rb MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)whole. Regional K1 values were calculated using this uniform global input function, which simplifies equations and enables robust estimation of MBF. To assess the robustness of the modified algorithm, interoperator repeatability of 3D 82Rb MBF was compared with a previously established method. Results. Whole LV correlation of 82Rb MBF with 15O-water MBF was better (P < .01) with the modified spillover correction method (r = 0.92 vs r = 0.60). The modified method also yielded significantly improved inter-operator repeatability of regional MBF quantification (r = 0.89) versus the established method (r = 0.82) (P < .01). Conclusion. A uniform global input function can suppress LV spillover into the imagederived blood input function, resulting in improved precision for MBF quantification with 3D 82Rb PET.
AB - Purpose. Myocardial blood flow (MBF) estimation with 82Rubidium (82Rb) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted leastsquares fitting. Methods. Fourteen volunteers underwent imaging with both 3-dimensional (3D) 82Rb and 15O-water PET at rest and during pharmacological stress. Whole left ventricular (LV) 82Rb MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)whole. Regional K1 values were calculated using this uniform global input function, which simplifies equations and enables robust estimation of MBF. To assess the robustness of the modified algorithm, interoperator repeatability of 3D 82Rb MBF was compared with a previously established method. Results. Whole LV correlation of 82Rb MBF with 15O-water MBF was better (P < .01) with the modified spillover correction method (r = 0.92 vs r = 0.60). The modified method also yielded significantly improved inter-operator repeatability of regional MBF quantification (r = 0.89) versus the established method (r = 0.82) (P < .01). Conclusion. A uniform global input function can suppress LV spillover into the imagederived blood input function, resulting in improved precision for MBF quantification with 3D 82Rb PET.
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U2 - 10.1007/s12350-012-9558-1
DO - 10.1007/s12350-012-9558-1
M3 - Article
C2 - 22527800
AN - SCOPUS:84865063117
VL - 19
SP - 763
EP - 774
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
IS - 4
ER -