Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model

Chietsugu Katoh, Keiichiro Yoshinaga, Ran Klein, Katsuhiko Kasai, Yuuki Tomiyama, Osamu Manabe, Masanao Naya, Mamoru Sakakibara, Hiroyuki Tsutsui, Robert A. DeKemp, Nagara Tamaki

研究成果: Contribution to journalArticle査読

23 被引用数 (Scopus)

抄録

Purpose. Myocardial blood flow (MBF) estimation with 82Rubidium (82Rb) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted leastsquares fitting. Methods. Fourteen volunteers underwent imaging with both 3-dimensional (3D) 82Rb and 15O-water PET at rest and during pharmacological stress. Whole left ventricular (LV) 82Rb MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)whole. Regional K1 values were calculated using this uniform global input function, which simplifies equations and enables robust estimation of MBF. To assess the robustness of the modified algorithm, interoperator repeatability of 3D 82Rb MBF was compared with a previously established method. Results. Whole LV correlation of 82Rb MBF with 15O-water MBF was better (P < .01) with the modified spillover correction method (r = 0.92 vs r = 0.60). The modified method also yielded significantly improved inter-operator repeatability of regional MBF quantification (r = 0.89) versus the established method (r = 0.82) (P < .01). Conclusion. A uniform global input function can suppress LV spillover into the imagederived blood input function, resulting in improved precision for MBF quantification with 3D 82Rb PET.

本文言語英語
ページ(範囲)763-774
ページ数12
ジャーナルJournal of Nuclear Cardiology
19
4
DOI
出版ステータス出版済み - 8 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング
  • 循環器および心血管医学

フィンガープリント

「Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル