Quantitative structure‐activity study of insecticidal 2‐methoxy‐5‐(substituted‐phenyl)‐1, 3, 2‐oxazaphospholidine 2‐sulfides against Musca domestica L. by topical application

Akinori Hirashima, Yutaka Yoshii, Ryuko Takeya, Morifusa Eto

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

The quantitative relationship between the structure of 2‐methoxy‐5‐(substituted‐phenyl)‐1, 3, 2‐oxazaphospholidine 2‐sulfides (5‐PMOS) and their insecticidal activity against the house fly. Musca domestica L., was analyzed using reported physicochemical parameters and regression analysis. The electronic nature of the substituent on the phenyl group of 5‐PMOS has the most significant effect on the activity, followed by hydrophobic and steric effects; the optimum value of Σρ is zero and the more hydrophobic the substituents on the phenyl group, the higher the insecticidal activity. The plots of observed pLD50, values against calculated pLD50 values for compounds having substituents in the ortho‐position deviated downwards from those of compounds having substituents at the meta and/or para positions. This ortho‐effect, which reduces the insecticidal activity of compounds having substituents at the ortho‐position, was expressed by a dummy parameter D, which has the value 2 for di‐ortho‐substituted derivatives, 1 for mono‐ortho‐substituted derivatives and zero for others. Thus, the highest activity was obtained for 2‐methoxy‐5‐phenyl‐1, 3, 2‐oxazaphospholidine 2‐sulfide, and the activity was decreased by the introduction of any substituents on the phenyl group.

元の言語英語
ページ(範囲)223-226
ページ数4
ジャーナルPesticide Science
35
発行部数3
DOI
出版物ステータス出版済み - 1 1 1992

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Houseflies
topical application
Musca domestica
Diptera
Regression Analysis
electronics
regression analysis

All Science Journal Classification (ASJC) codes

  • Applied Microbiology and Biotechnology

これを引用

Quantitative structure‐activity study of insecticidal 2‐methoxy‐5‐(substituted‐phenyl)‐1, 3, 2‐oxazaphospholidine 2‐sulfides against Musca domestica L. by topical application. / Hirashima, Akinori; Yoshii, Yutaka; Takeya, Ryuko; Eto, Morifusa.

:: Pesticide Science, 巻 35, 番号 3, 01.01.1992, p. 223-226.

研究成果: ジャーナルへの寄稿記事

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abstract = "The quantitative relationship between the structure of 2‐methoxy‐5‐(substituted‐phenyl)‐1, 3, 2‐oxazaphospholidine 2‐sulfides (5‐PMOS) and their insecticidal activity against the house fly. Musca domestica L., was analyzed using reported physicochemical parameters and regression analysis. The electronic nature of the substituent on the phenyl group of 5‐PMOS has the most significant effect on the activity, followed by hydrophobic and steric effects; the optimum value of Σρ is zero and the more hydrophobic the substituents on the phenyl group, the higher the insecticidal activity. The plots of observed pLD50, values against calculated pLD50 values for compounds having substituents in the ortho‐position deviated downwards from those of compounds having substituents at the meta and/or para positions. This ortho‐effect, which reduces the insecticidal activity of compounds having substituents at the ortho‐position, was expressed by a dummy parameter D, which has the value 2 for di‐ortho‐substituted derivatives, 1 for mono‐ortho‐substituted derivatives and zero for others. Thus, the highest activity was obtained for 2‐methoxy‐5‐phenyl‐1, 3, 2‐oxazaphospholidine 2‐sulfide, and the activity was decreased by the introduction of any substituents on the phenyl group.",
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