Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction

Seiji Shinkai; Thomas C. Bruice

doi:10.1021/ja00803a064

Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction

Seiji Shinkai, Thomas C. Bruice

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

33 被引用数 (Scopus)

抄録

The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton¹ proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).

本文言語	英語
ページ（範囲）	7526-7528
ページ数	3
ジャーナル	Journal of the American Chemical Society
巻	95
号	22
DOI	https://doi.org/10.1021/ja00803a064
出版ステータス	出版済み - 10月 1 1973
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

触媒
化学 (全般)
生化学
コロイド化学および表面化学

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title = "Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction",

abstract = "The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton1 proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).",

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N2 - The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton1 proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).

AB - The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton1 proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).

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Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction

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!!!All Science Journal Classification (ASJC) codes

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