Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction

Seiji Shinkai; Thomas C. Bruice

doi:10.1021/ja00803a064

Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction

Seiji Shinkai, Thomas C. Bruice

研究成果: Contribution to journal › Article

32 引用（Scopus）

抜粋

The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton¹ proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).

元の言語	英語
ページ（範囲）	7526-7528
ページ数	3
ジャーナル	Journal of the American Chemical Society
巻	95
発行部数	22
DOI	https://doi.org/10.1021/ja00803a064
出版物ステータス	出版済み - 10 1 1973
外部発表	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja00803a064

フィンガープリント Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

これを引用

Shinkai, S., & Bruice, T. C. (1973). Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction. Journal of the American Chemical Society, 95(22), 7526-7528. https://doi.org/10.1021/ja00803a064

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abstract = "The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton1 proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).",

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