Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction

Seiji Shinkai; Thomas C. Bruice

doi:10.1021/ja00803a064

Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction

Seiji Shinkai, Thomas C. Bruice

研究成果: Contribution to journal › Article › 査読

32 被引用数 (Scopus)

抄録

The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton¹ proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).

本文言語	英語
ページ（範囲）	7526-7528
ページ数	3
ジャーナル	Journal of the American Chemical Society
巻	95
号	22
DOI	https://doi.org/10.1021/ja00803a064
出版ステータス	出版済み - 10 1 1973
外部発表	はい

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

文献へのアクセス

10.1021/ja00803a064

他のファイルとリンク

フィンガープリント「Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{a515ebc2c4624fc8999b7d775a84a886,

title = "Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction",

abstract = "The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton1 proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).",

author = "Seiji Shinkai and Bruice, {Thomas C.}",

year = "1973",

month = oct,

day = "1",

doi = "10.1021/ja00803a064",

language = "English",

volume = "95",

pages = "7526--7528",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "22",

}

TY - JOUR

T1 - Question of Covalent Intermediate Formation in the Flavine-Catalyzed Carbonyl to Carbinol Oxidation-Reduction Reaction

AU - Shinkai, Seiji

AU - Bruice, Thomas C.

PY - 1973/10/1

Y1 - 1973/10/1

N2 - The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton1 proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).

AB - The mechanisms by which flavoenzymes catalyze oxidation-reduction reactions are of much concern. We address ourselves herein to the interconversion of aldehydes (ketones) and alcohols coupled to the oxidation-reduction of flavine. In a study of the oxidation of 10-phenylisoalloxazine Brown and Hamilton1 proposed 4a addition of alkoxide followed by base-catalyzed elimination of ketone (eq 1).

UR - http://www.scopus.com/inward/record.url?scp=0008258981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0008258981&partnerID=8YFLogxK

U2 - 10.1021/ja00803a064

DO - 10.1021/ja00803a064

M3 - Article

AN - SCOPUS:0008258981

VL - 95

SP - 7526

EP - 7528

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 22

ER -