Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation

Shinkichi Takamori, Gouji Toyokawa, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Nobutaka Mukae, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Toru Iwaki, Koji Iihara, Hiroshi Honda, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抜粋

Aim: To investigate the radiological features on computed tomography (CT) of brain metastasis (BM) from epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). Patients and Methods: Thirty-four patients with NSCLC with BMs who underwent surgical resection of the BMs at the Department of Neurosurgery, Kyushu University from 2005 to 2016 were enrolled in the study. The EGFR statuses of the 34 BMs were investigated. Radiological features, including the number, size, and location of the tumor, were delineated by CT. Results: Patients with EGFR-mutated BMs had significantly higher frequencies of multiple metastases than those with the non-EGFR-mutated type (p=0.042). BMs harboring mutations in EGFR were more frequently observed in the central area of the brain compared to those without mutations in EGFR (p=0.037). Conclusion: Careful follow-up of patients with EGFR-mutated NSCLC may be necessary given the high frequencies of multiple BMs and their location in the central area of the brain.

元の言語英語
ページ(範囲)3731-3734
ページ数4
ジャーナルAnticancer research
38
発行部数6
DOI
出版物ステータス出版済み - 6 2018

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Takamori, S., Toyokawa, G., Shimokawa, M., Kinoshita, F., Kozuma, Y., Matsubara, T., ... Maehara, Y. (2018). Radiological features of brain metastases from non-small cell lung cancer harboring EGFR mutation. Anticancer research, 38(6), 3731-3734. https://doi.org/10.21873/anticanres.12653