RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121

Takeshi Sekiguchi, Nobuaki Furuno, Takashi Ishii, Eiji Hirose, Fumiko Sekiguchi, Yonggang Wang, Hideki Kobayashi

研究成果: ジャーナルへの寄稿記事

抄録

Small Ras-like GTPases act as molecular switches for various signal transduction pathways. RagA, RagB/RagC and RagD are small Ras-like GTPases that play regulatory roles in mTORC1. Lack of proper activation of mTORC1 can lead to diseases, such as cancer and diabetes. In this study, we found an interaction between RagA and WDR35. Mutations of WDR35 may cause genetic diseases including Sensenbrenner syndrome. WDR35 seems to be a hedgehog signaling protein with a possible ciliary function and a possible upstream regulator of RagA. RagB is a homologue of RagA and is also associated with WDR35. WDR35 is present in the endoplasmic reticulum, but usually not in lysosomes, where Rag family proteins act as an mTORC1 switch. Over-expression of WDR35 results in decreased phosphorylation of ribosome S6 protein in a RagA-, RagB- and RagC-dependent manner. Thus, WDR35 is associated with RagA, RagB and RagC and might negatively influence mTORC1 activity.

元の言語英語
ページ(範囲)151-161
ページ数11
ジャーナルGenes to Cells
24
発行部数2
DOI
出版物ステータス出版済み - 2 1 2019

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Hedgehog Proteins
ras Proteins
Monomeric GTP-Binding Proteins
S 6
Inborn Genetic Diseases
Lysosomes
Ribosomes
Endoplasmic Reticulum
Signal Transduction
Proteins
Phosphorylation
Mutation
mechanistic target of rapamycin complex 1
Neoplasms

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cell Biology

これを引用

Sekiguchi, T., Furuno, N., Ishii, T., Hirose, E., Sekiguchi, F., Wang, Y., & Kobayashi, H. (2019). RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121. Genes to Cells, 24(2), 151-161. https://doi.org/10.1111/gtc.12663

RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121. / Sekiguchi, Takeshi; Furuno, Nobuaki; Ishii, Takashi; Hirose, Eiji; Sekiguchi, Fumiko; Wang, Yonggang; Kobayashi, Hideki.

:: Genes to Cells, 巻 24, 番号 2, 01.02.2019, p. 151-161.

研究成果: ジャーナルへの寄稿記事

Sekiguchi, T, Furuno, N, Ishii, T, Hirose, E, Sekiguchi, F, Wang, Y & Kobayashi, H 2019, 'RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121', Genes to Cells, 巻. 24, 番号 2, pp. 151-161. https://doi.org/10.1111/gtc.12663
Sekiguchi, Takeshi ; Furuno, Nobuaki ; Ishii, Takashi ; Hirose, Eiji ; Sekiguchi, Fumiko ; Wang, Yonggang ; Kobayashi, Hideki. / RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121. :: Genes to Cells. 2019 ; 巻 24, 番号 2. pp. 151-161.
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