Random migration contributes to cytotoxicity of activated CD8+ T-lymphocytes but not NK cells

Hideya Onishi, Akifumi Kiyota, Norihiro Koya, Hiroto Tanaka, Masayo Umebayashi, Mitsuo Katano, Takashi Morisaki

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

Activated lymphocytes have the ability to undergo non-directional cell movement known as random migration, although the biological role for this remains unclear. Herein, we investigated how random migration affects cytotoxicity of activated lymphocytes using time-lapse imaging analysis. The kinetics of random migration paralleled cytotoxicity in activated lymphocytes. Sphingosine-1-phosphate (S1P) and its receptor-1 (S1PR1) play an important role in lymphocyte migration. Phosphorylated FTY720 (FTYP), a structural analog of S1P, significantly inhibited random migration and cytotoxicity of activated CD3+NKG2D+ CD8+ T-lymphocytes but not CD3-NKG2D+CD56+ natural killer (NK) cells. In a mouse xenograft model, FTYP-treated activated lymphocytes exhibited lower cytotoxicity and less tumor infiltration for activated CD3+ NKG2D+ T-lymphocytes but not CD3-NKG2D+ NK cells. These results suggest that random migration contributes to the cytotoxicity of activated CD8+ T-cells but not of NK cells.

本文言語英語
ページ(範囲)3947-3956
ページ数10
ジャーナルAnticancer research
34
8
出版ステータス出版済み - 8月 1 2014

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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