Randomized comparison of pitavastatin and pravastatin treatment on the reduction of urinary albumin in patients with type 2 diabetic nephropathy

S. Kimura, T. Inoguchi, H. Yokomizo, Y. Maeda, Noriyuki Sonoda, R. Takayanagi

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

The effect of pitavastatin and pravastatin treatment on renal function was compared in type 2 diabetic patients with nephropathy in a randomized, controlled, open-label, parallel and multi-centre study. Type 2 diabetic patients with modest renal impairment (serum creatinine level <1.4 mg/dl) accompanied by albuminuria (30-600 mg/g creatinine) were randomly assigned to receive 2 mg of pitavastatin (n = 44) or 10 mg of pravastatin (n = 43) for 12 months. At 12 months, pitavastatin significantly reduced urinary albumin-to-creatinine ratio than pravastatin in subjects with macroalbuminuria (-67.2% vs. +14.5%, p = 0.0040), but not in subjects with microalbuminuria. There was no significant difference in the change in estimated glomerular filtration rate between the two groups. Pitavastatin is more effective than pravastatin for the reduction of albuminuria in type 2 diabetic patients with early stage of diabetic nephropathy.

元の言語英語
ページ(範囲)666-669
ページ数4
ジャーナルDiabetes, Obesity and Metabolism
14
発行部数7
DOI
出版物ステータス出版済み - 7 1 2012

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Pravastatin
Diabetic Nephropathies
Albumins
Creatinine
Albuminuria
Kidney
Therapeutics
Glomerular Filtration Rate
pitavastatin
Serum

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

Randomized comparison of pitavastatin and pravastatin treatment on the reduction of urinary albumin in patients with type 2 diabetic nephropathy. / Kimura, S.; Inoguchi, T.; Yokomizo, H.; Maeda, Y.; Sonoda, Noriyuki; Takayanagi, R.

:: Diabetes, Obesity and Metabolism, 巻 14, 番号 7, 01.07.2012, p. 666-669.

研究成果: ジャーナルへの寄稿記事

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AU - Inoguchi, T.

AU - Yokomizo, H.

AU - Maeda, Y.

AU - Sonoda, Noriyuki

AU - Takayanagi, R.

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AB - The effect of pitavastatin and pravastatin treatment on renal function was compared in type 2 diabetic patients with nephropathy in a randomized, controlled, open-label, parallel and multi-centre study. Type 2 diabetic patients with modest renal impairment (serum creatinine level <1.4 mg/dl) accompanied by albuminuria (30-600 mg/g creatinine) were randomly assigned to receive 2 mg of pitavastatin (n = 44) or 10 mg of pravastatin (n = 43) for 12 months. At 12 months, pitavastatin significantly reduced urinary albumin-to-creatinine ratio than pravastatin in subjects with macroalbuminuria (-67.2% vs. +14.5%, p = 0.0040), but not in subjects with microalbuminuria. There was no significant difference in the change in estimated glomerular filtration rate between the two groups. Pitavastatin is more effective than pravastatin for the reduction of albuminuria in type 2 diabetic patients with early stage of diabetic nephropathy.

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