Rapid production of pancreatic carcinoma by initiation with N-Nitroso-bis(2-oxopropyl)amine and repeated augmentation pressure in hamsters

Kazuhiro Mizumoto, Masahiro Tsutsumi, Ayumi Denda, Yoichi Konishi

研究成果: ジャーナルへの寄稿記事

57 引用 (Scopus)

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A rapid-production model incorporating the principle of selection by resistance to cytotoxicity demonstrated earlier for liver carcinogenesis in rats was established for pancreatic carcinoma development in Syrian hamsters. Adenocarcinomas were induced in 84% of treated animals by 10 weeks after initiation with 70 mg of N-nitroso-bis(2-oxopropyl)amine (BOP) per kg of body weight when augmentation pressure (choline-deficient diet combined with DL-ethionine and L-methionine and administration of 20 mg/kg BOP upon return to basal diet) was applied three times. A 52% yield of cholanglocellular tumors also resulted from this experimental protocol. [J Natl Cancer Inst 1988;80:1564-1567]

元の言語英語
ページ(範囲)1564-1567
ページ数4
ジャーナルJournal of the National Cancer Institute
80
発行部数19
DOI
出版物ステータス出版済み - 7 7 1988

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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