Rate enhancement with high ratio of the monoalkylated product to the dialkylated product in the alkylation of the lithium enolate of 1-tetralone with reactive alkyl halides

M. Goto, K. I. Akimoto, K. Aoki, M. Shindo, K. Koga

研究成果: Contribution to journalArticle

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The reactions of the lithium enolate of 1-tetralone with reactive alkyl halides were examined in the absence and in the presence of 3 eq of various ligands for the lithium. It is shown that the rates of the reactions are enhanced greatly in the presence a tetradentate amine (1,1,4,7,10,10-hexamethyltriethylenetetramine), and the ratio of the monoalkylated product to the dialkylated product is increased under shorter reaction times.

元の言語英語
ページ(範囲)1529-1531
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
48
発行部数10
DOI
出版物ステータス出版済み - 1 1 2000
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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