RBPJ and MAML3: Potential therapeutic targets for small cell lung cancer

Hideya Onishi, Shu Ichimiya, Kosuke Yanai, Masayo Umebayashi, Katsuya Nakamura, Akio Yamasaki, Akira Imaizumi, Shuntaro Nagai, Mutsunori Murahashi, Hisanobu Ogata, Takashi Morisaki

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Background/Aim: Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule targeting agent is urgently desired. Previously we showed that recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and mastermindlike 3 (MAML3) are new therapeutic targets for pancreatic cancer. In the present study, we analyzed whether RBPJ/MAML3 inhibition could also be a new therapeutic strategy for SCLC. Materials and Methods: Using silencing of RBPJ/MAML3, proliferation, invasion, migration and chemosensitivity of SBC-5 cells were investigated. Results: RBPJ/MAML3 inhibition reduced Smoothened and HES1 expression, suggesting that RBPJ/MAML3 signaling was through Hedgehog and NOTCH pathways. In the analysis of cell functions, RBPJ/MAML3 inhibition significantly reduced proliferation and invasiveness via reduction of expression of matrix metalloproteinases. On the other hand, RBPJ/MAML3 inhibition also reduced chemosensitivity to cis-diamminedichlo-roplatinum and gemcitabine. Conclusion: These results suggest that RBPJ and MAML3 could be new therapeutic targets for SCLC, however, chemosensitivity may be reduced in combinational use with other chemo-therapeutic agents.

本文言語英語
ページ(範囲)4543-4547
ページ数5
ジャーナルAnticancer research
38
8
DOI
出版ステータス出版済み - 8 2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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