Reaction of magnesium cyclopropylidene with N-lithio arylamines: a method for generation of α-amino-substituted cyclopropylmagnesiums and a study for their reactivity with electrophiles

Tsuyoshi Satoh, Mariko Miura, Ken Sakai, Yoshimi Yokoyama

研究成果: Contribution to journalArticle査読

40 被引用数 (Scopus)

抄録

Magnesium cyclopropylidene was generated from 1-chlorocyclopropyl phenyl sulfoxide with i-PrMgCl in THF at -78 °C in high yield by a sulfoxide-magnesium exchange reaction. The generated magnesium cyclopropylidene was found to be reactive with N-lithio arylamines to give α-amino-substituted cyclopropylmagnesiums. The reaction of the α-amino-substituted cyclopropylmagnesiums with several electrophiles was examined and a new method for a synthesis of cyclopropane amino acid derivatives was realized.

本文言語英語
ページ(範囲)4253-4261
ページ数9
ジャーナルTetrahedron
62
17
DOI
出版ステータス出版済み - 4 24 2006

All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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