Rearrangement of immunoglobulin heavy chain genes and t3 expression in the absence of rearrangement of t-cell receptor β-chain gene in a patient with t-cell malignant lymphoma

Hiroyasu Ogawa, Haruo Sugiyama, Yoshihiro Oka, Toyoki Maeda, Toshihisa Komori, Yoshihiko Tani, Seigou Miyake, Toshihiro Soma, Ryoji Maekura, Chikao Yutani, Tohru Masaoka, Susumu Kishimoto

研究成果: Contribution to journalArticle

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We describe the rearrangement of immunoglobulin genes and T3 expression in the absence of rearrangement of T-cell receptor β-chain genes in a patient wih T-cell malignant lymphoma. He had a mediastinal mass and his lymphoma cells expressed T-cell antigens (OKT3+, OKT9+, and OKT10+). When we examined genomic DNA from the lymphoma cells, we detected the rearrangement of immunoglobulin heavy chain genes with a germ-line configuration of light chain genes and no rearrangement of T-cell receptor β-chain gene. These results indicated that the rearrangement of immunoglobulin genes could occur in T-cell malignant lymphoma, and that T3 antigen could be expressed prior to the rearrangement of T-cell receptor β-chain genes under certain circumstances.

元の言語英語
ページ(範囲)1369-1375
ページ数7
ジャーナルLeukemia Research
10
発行部数12
DOI
出版物ステータス出版済み - 1986
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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