Recent advances in Cannabis sativa research: Biosynthetic studies and its potential in biotechnology

Supaart Sirikantaramas, Futoshi Taura, Satoshi Morimoto, Yukihiro Shoyama

研究成果: ジャーナルへの寄稿総説査読

64 被引用数 (Scopus)

抄録

Cannabinoids, consiting of alkylresorcinol and monoterpene groups, are the unique secondary metabolites that are found only in Cannabis sativa. Tetrahydrocannabinol (THQ, cannabidiol (CBD) and cannabichromene (CBQ are well known cannabinoids and their pharmacological properties have been extensively studied. Recently, biosynthetic pathways of these cannabinoids have been successfully established. Several biosynthetic enzymes including geranylpyrophosphate: olivetolate geranyltransferase, tetrahydrocannabinolic acid (THCA) synthase, cannabidiolic acid (CBDA) synthase and cannabigerolic acid (CBCA) synthase have been purified from young rapidly expanding leaves of C. sativa. In addition, molecular cloning, characterization and localization of THCA synthase have been recently reported. THCA and cannabigerolic acid (CBGA), its substrate, were shown to be apoptosis-inducing agents that might play a role in plant defense. Transgenic tobacco hairy roots expressing THCA synthase can produce THCA upon feeding. of CBGA. These results open the way for biotechnological production of cannabinoids in the future.

本文言語英語
ページ(範囲)237-243
ページ数7
ジャーナルCurrent Pharmaceutical Biotechnology
8
4
DOI
出版ステータス出版済み - 8月 1 2007

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 薬科学

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