Recent Advances in Systemic Chemotherapy for Metastatic Colorectal Cancer

Yuji Miyamoto, Eiji Oki, Hiroshi Saeki, Yoshihiko Maehara, Hideo Baba

研究成果: Contribution to journalReview article査読

2 被引用数 (Scopus)


The recent development of chemotherapeutic agents and biomarkers have remarkably improved treatment outcomes of metastatic colorectal cancer (mCRC). However, decision making regarding the choice of therapy for mCRC has been complicated by the availability of many different treatment options. In this review, we will discuss the clinical evidence for current systemic treatment, including the key roles of 3 cytotoxic drugs and oral fluoropyrimidines, the appropriate use of anti-VEGF and anti-EGFR therapy, the significance of RAS mutation status as a predictive marker for anti-EGFR therapy, and new agents for salvage therapy (regorafenib and TAS-102 [TFTD]).

ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
出版ステータス出版済み - 1 1 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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