Recent progress in understanding the mechanisms of Leydig cell differentiation

研究成果: ジャーナルへの寄稿評論記事

3 引用 (Scopus)

抄録

Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells.

元の言語英語
ページ(範囲)39-46
ページ数8
ジャーナルMolecular and Cellular Endocrinology
468
DOI
出版物ステータス出版済み - 6 15 2018

Fingerprint

Leydig Cells
Androgens
Cell Differentiation
Genes
Testis
Genome

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

これを引用

Recent progress in understanding the mechanisms of Leydig cell differentiation. / Inoue, Miki; Baba, Takashi; Morohashi, Ken-Ichirou.

:: Molecular and Cellular Endocrinology, 巻 468, 15.06.2018, p. 39-46.

研究成果: ジャーナルへの寄稿評論記事

@article{88b3c9c02c9a4f4aa86b522a7706f627,
title = "Recent progress in understanding the mechanisms of Leydig cell differentiation",
abstract = "Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells.",
author = "Miki Inoue and Takashi Baba and Ken-Ichirou Morohashi",
year = "2018",
month = "6",
day = "15",
doi = "10.1016/j.mce.2017.12.013",
language = "English",
volume = "468",
pages = "39--46",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Recent progress in understanding the mechanisms of Leydig cell differentiation

AU - Inoue, Miki

AU - Baba, Takashi

AU - Morohashi, Ken-Ichirou

PY - 2018/6/15

Y1 - 2018/6/15

N2 - Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells.

AB - Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells.

UR - http://www.scopus.com/inward/record.url?scp=85042694364&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042694364&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2017.12.013

DO - 10.1016/j.mce.2017.12.013

M3 - Review article

C2 - 29309805

AN - SCOPUS:85042694364

VL - 468

SP - 39

EP - 46

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

ER -