Transition metal-catalysed C-H transformations are powerful methods to obtain functionalised organic molecules from simple starting materials. Controlling regioselectivity is one of the most important issues in C-H transformations. Since the remarkable work by Murai and co-workers in 1993, many groups have reportedortho-selective C(sp2)-H transformations using directing group methods, in which interactions exist between substrates and catalytically active metal centres. In this review, new methodologies to achieve regioselective C-H transformations are described. In these methhodologies, noncovalent interactions between substrates and reagents or ligands of catalysts play important roles. In these cases, selective functionalization of remote C-H bonds, such asmeta- andpara-C-H bonds, can also be realized.
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