Reciprocal modulation of sweet taste by leptin and endocannabinoids

Mayu Niki, Masafumi Jyotaki, Ryusuke Yoshida, Yuzo Ninomiya

研究成果: 書籍/レポート タイプへの寄稿

22 被引用数 (Scopus)


Sweet taste perception is important for animals to detect carbohydrate source of calories and has a critical role in the nutritional status of animals. Recent studies demonstrated that sweet taste responses can be modulated by leptin and endocannabinoids [anandamide (N-arachidonoylethanolamine) and 2-arachidonoyl glycerol]. Leptin is an anorexigenic mediator that reduces food intake by acting on hypothalamic receptor, Ob-Rb. Leptin is shown to selectively suppress sweet taste responses in wild-type mice but not in leptin receptor-deficient db/db mice. In marked contrast, endocannabinoids are orexigenic mediators that act via CB1 receptors in hypothalamus and limbic forebrain to induce appetite and stimulate food intake. In the peripheral taste system, endocannabinoids also oppose the action of leptin and enhance sweet taste sensitivities in wild-type mice but not in mice genetically lacking CB1 receptors. These findings indicate that leptin and endocannabinoids not only regulate food intake via central nervous systems but also may modulate palatability of foods by altering peripheral sweet taste responses via their cognate receptors.

ホスト出版物のタイトルSensory and Metabolic Control of Energy Balance
編集者Wolfgang Meyerhof, Hans-Georg Joost, Ulrike Beisiegel
出版ステータス出版済み - 10月 14 2010


名前Results and Problems in Cell Differentiation

!!!All Science Journal Classification (ASJC) codes

  • 発生生物学
  • 細胞生物学


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