Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

Toshio Kukita; Junji Nakao; Fukusaburo Hamada; Akiko Kukita; Tetsuichiro Inai; Kojiro Kurisu; Hisayuki Nomiyama

doi:10.1016/0169-6009(92)90871-A

Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

Toshio Kukita, Junji Nakao, Fukusaburo Hamada, Akiko Kukita, Tetsuichiro Inai, Kojiro Kurisu, Hisayuki Nomiyama

口腔常態制御学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

19 被引用数 (Scopus)

抄録

Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D₃. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.

本文言語	英語
ページ（範囲）	215-223
ページ数	9
ジャーナル	Bone and Mineral
巻	19
号	3
DOI	https://doi.org/10.1016/0169-6009(92)90871-A
出版ステータス	出版済み - 12月 1992

!!!All Science Journal Classification (ASJC) codes

外科
生化学
内分泌学

文献へのアクセス

10.1016/0169-6009(92)90871-A

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引用スタイル

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abstract = "Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D3. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.",

author = "Toshio Kukita and Junji Nakao and Fukusaburo Hamada and Akiko Kukita and Tetsuichiro Inai and Kojiro Kurisu and Hisayuki Nomiyama",

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T1 - Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system

AU - Kukita, Toshio

AU - Nakao, Junji

AU - Hamada, Fukusaburo

AU - Kukita, Akiko

AU - Inai, Tetsuichiro

AU - Kurisu, Kojiro

AU - Nomiyama, Hisayuki

PY - 1992/12

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N2 - Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D3. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.

AB - Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78α and its variant LD78β proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1α,25-dihydroxyvitamin D3. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.

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