Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice

Yohji A. Minamishima, Keiko Nakayama, Keiichi Nakayama

研究成果: ジャーナルへの寄稿記事

54 引用 (Scopus)

抄録

The abundance of p27Kip1, an inhibitor of cell proliferation, is determined by Skp2-dependent proteolysis, the deregulation of which is associated with cancer progression. Lack of Skp2 results in p27Kip1 accumulation as well as enlargement and polyploidy of hepatocytes. The role of Skp2 in cell growth and proliferation was investigated in Skp2-deficient mice subjected to partial hepatectomy. Skp2-/- mice exhibited restoration of liver mass without cell proliferation; rather, hepatocytes increased in size, an effect that was accompanied by increased polyploidy and p27Kip1 accumulation. Lack of Skp2 thus impairs hepatocyte proliferation, which is compensated for by cellular enlargement, during liver regeneration.

元の言語英語
ページ(範囲)995-999
ページ数5
ジャーナルCancer Research
62
発行部数4
出版物ステータス出版済み - 2002

Fingerprint

Hepatectomy
Hepatocytes
Polyploidy
Cell Proliferation
Liver
Liver Regeneration
Proteolysis
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

これを引用

Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. / Minamishima, Yohji A.; Nakayama, Keiko; Nakayama, Keiichi.

:: Cancer Research, 巻 62, 番号 4, 2002, p. 995-999.

研究成果: ジャーナルへの寄稿記事

@article{ca0b056c9f8148f5bbef0136c770dc8d,
title = "Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice",
abstract = "The abundance of p27Kip1, an inhibitor of cell proliferation, is determined by Skp2-dependent proteolysis, the deregulation of which is associated with cancer progression. Lack of Skp2 results in p27Kip1 accumulation as well as enlargement and polyploidy of hepatocytes. The role of Skp2 in cell growth and proliferation was investigated in Skp2-deficient mice subjected to partial hepatectomy. Skp2-/- mice exhibited restoration of liver mass without cell proliferation; rather, hepatocytes increased in size, an effect that was accompanied by increased polyploidy and p27Kip1 accumulation. Lack of Skp2 thus impairs hepatocyte proliferation, which is compensated for by cellular enlargement, during liver regeneration.",
author = "Minamishima, {Yohji A.} and Keiko Nakayama and Keiichi Nakayama",
year = "2002",
language = "English",
volume = "62",
pages = "995--999",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "4",

}

TY - JOUR

T1 - Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice

AU - Minamishima, Yohji A.

AU - Nakayama, Keiko

AU - Nakayama, Keiichi

PY - 2002

Y1 - 2002

N2 - The abundance of p27Kip1, an inhibitor of cell proliferation, is determined by Skp2-dependent proteolysis, the deregulation of which is associated with cancer progression. Lack of Skp2 results in p27Kip1 accumulation as well as enlargement and polyploidy of hepatocytes. The role of Skp2 in cell growth and proliferation was investigated in Skp2-deficient mice subjected to partial hepatectomy. Skp2-/- mice exhibited restoration of liver mass without cell proliferation; rather, hepatocytes increased in size, an effect that was accompanied by increased polyploidy and p27Kip1 accumulation. Lack of Skp2 thus impairs hepatocyte proliferation, which is compensated for by cellular enlargement, during liver regeneration.

AB - The abundance of p27Kip1, an inhibitor of cell proliferation, is determined by Skp2-dependent proteolysis, the deregulation of which is associated with cancer progression. Lack of Skp2 results in p27Kip1 accumulation as well as enlargement and polyploidy of hepatocytes. The role of Skp2 in cell growth and proliferation was investigated in Skp2-deficient mice subjected to partial hepatectomy. Skp2-/- mice exhibited restoration of liver mass without cell proliferation; rather, hepatocytes increased in size, an effect that was accompanied by increased polyploidy and p27Kip1 accumulation. Lack of Skp2 thus impairs hepatocyte proliferation, which is compensated for by cellular enlargement, during liver regeneration.

UR - http://www.scopus.com/inward/record.url?scp=0036172085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036172085&partnerID=8YFLogxK

M3 - Article

C2 - 11861371

AN - SCOPUS:0036172085

VL - 62

SP - 995

EP - 999

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 4

ER -