Redox molecular imaging using ReMI

Fuminori Hyodo, Shinji Ito, Hideo Utsumi

    研究成果: ジャーナルへの寄稿記事

    1 引用 (Scopus)

    抄録

    Tissue redox status is one of the most important parameters to maintain homeostasis in the living body. Numerous redox reactions are involved in metabolic processes, such as energy production in the mitochondrial electron transfer system. A variety of intracellular molecules such as reactive oxygen species, glutathione, thioredoxins, NADPH, ‰avins, and ascorbic acid may contribute to the overall redox status in tissues. Breakdown of redox balance may lead to oxida- tive stress and can induce many pathological conditions such as cancer, neurological disorders, and aging. Therefore im- aging of tissue redox status and monitoring antioxidant levels in living organisms can be useful in the diagnosis of dis- ease states and assessment of treatment response. In vivo redox molecular imaging technology such as electron spin resonance imaging (ESRI), magnetic resonance imaging (MRI), and dynamic nuclear polarization (DNP)-MRI (redox molecular imaging; ReMI) is emerging as a viable redox status imaging modality. This review focuses on the application of magnetic resonance technologies using MRI or DNP-MRI and redox-sensitive contrast agents.

    元の言語英語
    ページ(範囲)725-731
    ページ数7
    ジャーナルYakugaku Zasshi
    135
    発行部数5
    DOI
    出版物ステータス出版済み - 1 1 2015

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    Molecular Imaging
    Oxidation-Reduction
    Magnetic Resonance Imaging
    Magnetic Resonance Spectroscopy
    Technology
    Thioredoxins
    Electron Spin Resonance Spectroscopy
    Nervous System Diseases
    NADP
    Contrast Media
    Ascorbic Acid
    Glutathione
    Reactive Oxygen Species
    Oxidative Stress
    Homeostasis
    Antioxidants
    Electrons

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Pharmaceutical Science

    これを引用

    Hyodo, F., Ito, S., & Utsumi, H. (2015). Redox molecular imaging using ReMI. Yakugaku Zasshi, 135(5), 725-731. https://doi.org/10.1248/yakushi.14-00235-2

    Redox molecular imaging using ReMI. / Hyodo, Fuminori; Ito, Shinji; Utsumi, Hideo.

    :: Yakugaku Zasshi, 巻 135, 番号 5, 01.01.2015, p. 725-731.

    研究成果: ジャーナルへの寄稿記事

    Hyodo, F, Ito, S & Utsumi, H 2015, 'Redox molecular imaging using ReMI', Yakugaku Zasshi, 巻. 135, 番号 5, pp. 725-731. https://doi.org/10.1248/yakushi.14-00235-2
    Hyodo, Fuminori ; Ito, Shinji ; Utsumi, Hideo. / Redox molecular imaging using ReMI. :: Yakugaku Zasshi. 2015 ; 巻 135, 番号 5. pp. 725-731.
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