Redox regulation of the actin cytoskeleton and its role in the vascular system

Qian Xu, Lauren P. Huff, Masakazu Fujii, Kathy K. Griendling

研究成果: Contribution to journalReview article査読

23 被引用数 (Scopus)

抄録

The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical, organizational and signaling roles. Because many cytoskeletal proteins are sensitive to reactive oxygen species, redox regulation has emerged as a pivotal modulator of the actin cytoskeleton and its associated proteins. Here, we summarize work implicating oxidants in altering actin cytoskeletal proteins and focus on how these alterations affect cell migration, proliferation and contraction of vascular cells. Finally, we discuss the role of oxidative modification of the actin cytoskeleton in vivo and highlight its importance for vascular diseases.

本文言語英語
ページ(範囲)84-107
ページ数24
ジャーナルFree Radical Biology and Medicine
109
DOI
出版ステータス出版済み - 8 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology (medical)

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