Reduced arterial stiffness in patients with acromegaly: Noninvasive assessment by the cardio-ankle vascular index (CAVI)

Yayoi Matsuda, Hisaya Kawate, Chitose Matsuzaki, Ryuichi Sakamoto, Ichiro Abe, Kimitaka Shibue, Michiko Kohno, Masahiro Adachi, Keizo Ohnaka, Masatoshi Nomura, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

In patients with acromegaly, cardiovascular diseases are the most common cause of death. Arterial stiffness is increasingly recognized as a valuable surrogate marker for predicting cardiovascular events. To evaluate the vascular status of acromegalic patients, we used the cardio-ankle vascular index (CAVI) to reflect the arterial stiffness from the heart to the ankles. We analyzed 21 acromegalic patients, comprising five patients with untreated active acromegaly, one patient treated with medication and 15 patients who underwent transsphenoidal surgery. Among the 15 patients with surgery, 10 received additional therapies with dopamine agonists and/or somatostatin analogs. All patients with acromegaly unexpectedly showed significant reductions in the CAVI, indicating reduced arterial stiffness, compared with age- and sex-matchedcontrols, regardless of whether they underwent surgery. There was a significant negative correlation between the CAVI and the serum insulin-like growth factor (IGF)-I level in these patients. Active acromegalic patients were associated with lower CAVI than controlled patients. Sequential measurements of the CAVI and serum IGF-I before and after treatment with octreotide and transsphenoidal surgery revealed that a reduced IGF-I level after treatment was accompanied by CAVI elevation. The present findings indicate that the CAVI is negatively correlated with the serum IGF-I level in acromegaly. These findings are consistent with previous reports indicating that the GH/IGF-I axis reduces peripheral vascular resistance. This non-invasive assessment can reflect the present vascular status and would be a useful marker for evaluation of therapeutic effects in patients with acromegaly.

元の言語英語
ページ(範囲)29-36
ページ数8
ジャーナルEndocrine Journal
60
発行部数1
DOI
出版物ステータス出版済み - 2 13 2013

Fingerprint

Vascular Stiffness
Acromegaly
Ankle
Blood Vessels
Insulin-Like Growth Factor I
Vascular Resistance
Serum
Octreotide
Dopamine Agonists
Therapeutic Uses
Somatostatin
Cause of Death
Cardiovascular Diseases
Therapeutics
Biomarkers

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

Reduced arterial stiffness in patients with acromegaly : Noninvasive assessment by the cardio-ankle vascular index (CAVI). / Matsuda, Yayoi; Kawate, Hisaya; Matsuzaki, Chitose; Sakamoto, Ryuichi; Abe, Ichiro; Shibue, Kimitaka; Kohno, Michiko; Adachi, Masahiro; Ohnaka, Keizo; Nomura, Masatoshi; Takayanagi, Ryoichi.

:: Endocrine Journal, 巻 60, 番号 1, 13.02.2013, p. 29-36.

研究成果: ジャーナルへの寄稿記事

Matsuda, Yayoi ; Kawate, Hisaya ; Matsuzaki, Chitose ; Sakamoto, Ryuichi ; Abe, Ichiro ; Shibue, Kimitaka ; Kohno, Michiko ; Adachi, Masahiro ; Ohnaka, Keizo ; Nomura, Masatoshi ; Takayanagi, Ryoichi. / Reduced arterial stiffness in patients with acromegaly : Noninvasive assessment by the cardio-ankle vascular index (CAVI). :: Endocrine Journal. 2013 ; 巻 60, 番号 1. pp. 29-36.
@article{169455356e4c4f9dbabdd2b0e533c30f,
title = "Reduced arterial stiffness in patients with acromegaly: Noninvasive assessment by the cardio-ankle vascular index (CAVI)",
abstract = "In patients with acromegaly, cardiovascular diseases are the most common cause of death. Arterial stiffness is increasingly recognized as a valuable surrogate marker for predicting cardiovascular events. To evaluate the vascular status of acromegalic patients, we used the cardio-ankle vascular index (CAVI) to reflect the arterial stiffness from the heart to the ankles. We analyzed 21 acromegalic patients, comprising five patients with untreated active acromegaly, one patient treated with medication and 15 patients who underwent transsphenoidal surgery. Among the 15 patients with surgery, 10 received additional therapies with dopamine agonists and/or somatostatin analogs. All patients with acromegaly unexpectedly showed significant reductions in the CAVI, indicating reduced arterial stiffness, compared with age- and sex-matchedcontrols, regardless of whether they underwent surgery. There was a significant negative correlation between the CAVI and the serum insulin-like growth factor (IGF)-I level in these patients. Active acromegalic patients were associated with lower CAVI than controlled patients. Sequential measurements of the CAVI and serum IGF-I before and after treatment with octreotide and transsphenoidal surgery revealed that a reduced IGF-I level after treatment was accompanied by CAVI elevation. The present findings indicate that the CAVI is negatively correlated with the serum IGF-I level in acromegaly. These findings are consistent with previous reports indicating that the GH/IGF-I axis reduces peripheral vascular resistance. This non-invasive assessment can reflect the present vascular status and would be a useful marker for evaluation of therapeutic effects in patients with acromegaly.",
author = "Yayoi Matsuda and Hisaya Kawate and Chitose Matsuzaki and Ryuichi Sakamoto and Ichiro Abe and Kimitaka Shibue and Michiko Kohno and Masahiro Adachi and Keizo Ohnaka and Masatoshi Nomura and Ryoichi Takayanagi",
year = "2013",
month = "2",
day = "13",
doi = "10.1507/endocrj.EJ12-0189",
language = "English",
volume = "60",
pages = "29--36",
journal = "Endocrine Journal",
issn = "0918-8959",
publisher = "Japan Endocrine Society",
number = "1",

}

TY - JOUR

T1 - Reduced arterial stiffness in patients with acromegaly

T2 - Noninvasive assessment by the cardio-ankle vascular index (CAVI)

AU - Matsuda, Yayoi

AU - Kawate, Hisaya

AU - Matsuzaki, Chitose

AU - Sakamoto, Ryuichi

AU - Abe, Ichiro

AU - Shibue, Kimitaka

AU - Kohno, Michiko

AU - Adachi, Masahiro

AU - Ohnaka, Keizo

AU - Nomura, Masatoshi

AU - Takayanagi, Ryoichi

PY - 2013/2/13

Y1 - 2013/2/13

N2 - In patients with acromegaly, cardiovascular diseases are the most common cause of death. Arterial stiffness is increasingly recognized as a valuable surrogate marker for predicting cardiovascular events. To evaluate the vascular status of acromegalic patients, we used the cardio-ankle vascular index (CAVI) to reflect the arterial stiffness from the heart to the ankles. We analyzed 21 acromegalic patients, comprising five patients with untreated active acromegaly, one patient treated with medication and 15 patients who underwent transsphenoidal surgery. Among the 15 patients with surgery, 10 received additional therapies with dopamine agonists and/or somatostatin analogs. All patients with acromegaly unexpectedly showed significant reductions in the CAVI, indicating reduced arterial stiffness, compared with age- and sex-matchedcontrols, regardless of whether they underwent surgery. There was a significant negative correlation between the CAVI and the serum insulin-like growth factor (IGF)-I level in these patients. Active acromegalic patients were associated with lower CAVI than controlled patients. Sequential measurements of the CAVI and serum IGF-I before and after treatment with octreotide and transsphenoidal surgery revealed that a reduced IGF-I level after treatment was accompanied by CAVI elevation. The present findings indicate that the CAVI is negatively correlated with the serum IGF-I level in acromegaly. These findings are consistent with previous reports indicating that the GH/IGF-I axis reduces peripheral vascular resistance. This non-invasive assessment can reflect the present vascular status and would be a useful marker for evaluation of therapeutic effects in patients with acromegaly.

AB - In patients with acromegaly, cardiovascular diseases are the most common cause of death. Arterial stiffness is increasingly recognized as a valuable surrogate marker for predicting cardiovascular events. To evaluate the vascular status of acromegalic patients, we used the cardio-ankle vascular index (CAVI) to reflect the arterial stiffness from the heart to the ankles. We analyzed 21 acromegalic patients, comprising five patients with untreated active acromegaly, one patient treated with medication and 15 patients who underwent transsphenoidal surgery. Among the 15 patients with surgery, 10 received additional therapies with dopamine agonists and/or somatostatin analogs. All patients with acromegaly unexpectedly showed significant reductions in the CAVI, indicating reduced arterial stiffness, compared with age- and sex-matchedcontrols, regardless of whether they underwent surgery. There was a significant negative correlation between the CAVI and the serum insulin-like growth factor (IGF)-I level in these patients. Active acromegalic patients were associated with lower CAVI than controlled patients. Sequential measurements of the CAVI and serum IGF-I before and after treatment with octreotide and transsphenoidal surgery revealed that a reduced IGF-I level after treatment was accompanied by CAVI elevation. The present findings indicate that the CAVI is negatively correlated with the serum IGF-I level in acromegaly. These findings are consistent with previous reports indicating that the GH/IGF-I axis reduces peripheral vascular resistance. This non-invasive assessment can reflect the present vascular status and would be a useful marker for evaluation of therapeutic effects in patients with acromegaly.

UR - http://www.scopus.com/inward/record.url?scp=84873494234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873494234&partnerID=8YFLogxK

U2 - 10.1507/endocrj.EJ12-0189

DO - 10.1507/endocrj.EJ12-0189

M3 - Article

C2 - 22986423

AN - SCOPUS:84873494234

VL - 60

SP - 29

EP - 36

JO - Endocrine Journal

JF - Endocrine Journal

SN - 0918-8959

IS - 1

ER -