Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ℰ1 subunit

Kenji Sakimura, Tatsuya Kutsuwada, Isao Ito, Toshiya Manabe, Chitoshi Takayama, Etsuko Kushiya, Takeshi Yagi, Aizawa Shinichi, Yoshiro Inoue, Hiroyuki Sugiyama, Masayoshi Mishina

研究成果: ジャーナルへの寄稿レター

609 引用 (Scopus)

抄録

THE NMDA (TV-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development1, 2. The NMDA receptor channel is formed by at least two members of the glutamate receptor (GluR) channel subunit families, the GluRε (NR2) and GiuRζ (NR1) sub-unit families3–8. The four ε subunits are distinct in distribution, properties and regulation5–14. On the basis of the Mg2+sensitivity and expression patterns, we have proposed that the εi (NR2A) and ε2 (NR2B) subunits play a role in synaptic plasticity6, 14. Here we show that targeted disruption of the mouse εl subunit gene resulted in significant reduction of the NMDA receptor channel current and long-term potentiation at the hippocampal CA1 synapses. The mutant mice also showed a moderate deficiency in spatial learning. These results support the notion that the NMDA receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning.

元の言語英語
ページ(範囲)151-155
ページ数5
ジャーナルNature
373
発行部数6510
DOI
出版物ステータス出版済み - 1 12 1995

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N-Methyl-D-Aspartate Receptors
Neuronal Plasticity
Glutamate Receptors
Learning
D-Aspartic Acid
Long-Term Potentiation
N-Methylaspartate
Synapses
Genes
Spatial Learning

All Science Journal Classification (ASJC) codes

  • General

これを引用

Sakimura, K., Kutsuwada, T., Ito, I., Manabe, T., Takayama, C., Kushiya, E., ... Mishina, M. (1995). Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ℰ1 subunit. Nature, 373(6510), 151-155. https://doi.org/10.1038/373151a0

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ℰ1 subunit. / Sakimura, Kenji; Kutsuwada, Tatsuya; Ito, Isao; Manabe, Toshiya; Takayama, Chitoshi; Kushiya, Etsuko; Yagi, Takeshi; Shinichi, Aizawa; Inoue, Yoshiro; Sugiyama, Hiroyuki; Mishina, Masayoshi.

:: Nature, 巻 373, 番号 6510, 12.01.1995, p. 151-155.

研究成果: ジャーナルへの寄稿レター

Sakimura, K, Kutsuwada, T, Ito, I, Manabe, T, Takayama, C, Kushiya, E, Yagi, T, Shinichi, A, Inoue, Y, Sugiyama, H & Mishina, M 1995, 'Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ℰ1 subunit', Nature, 巻. 373, 番号 6510, pp. 151-155. https://doi.org/10.1038/373151a0
Sakimura K, Kutsuwada T, Ito I, Manabe T, Takayama C, Kushiya E その他. Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ℰ1 subunit. Nature. 1995 1 12;373(6510):151-155. https://doi.org/10.1038/373151a0
Sakimura, Kenji ; Kutsuwada, Tatsuya ; Ito, Isao ; Manabe, Toshiya ; Takayama, Chitoshi ; Kushiya, Etsuko ; Yagi, Takeshi ; Shinichi, Aizawa ; Inoue, Yoshiro ; Sugiyama, Hiroyuki ; Mishina, Masayoshi. / Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ℰ1 subunit. :: Nature. 1995 ; 巻 373, 番号 6510. pp. 151-155.
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AU - Kushiya, Etsuko

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N2 - THE NMDA (TV-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development1, 2. The NMDA receptor channel is formed by at least two members of the glutamate receptor (GluR) channel subunit families, the GluRε (NR2) and GiuRζ (NR1) sub-unit families3–8. The four ε subunits are distinct in distribution, properties and regulation5–14. On the basis of the Mg2+sensitivity and expression patterns, we have proposed that the εi (NR2A) and ε2 (NR2B) subunits play a role in synaptic plasticity6, 14. Here we show that targeted disruption of the mouse εl subunit gene resulted in significant reduction of the NMDA receptor channel current and long-term potentiation at the hippocampal CA1 synapses. The mutant mice also showed a moderate deficiency in spatial learning. These results support the notion that the NMDA receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning.

AB - THE NMDA (TV-methyl-D-aspartate) receptor channel is important for synaptic plasticity, which is thought to underlie learning, memory and development1, 2. The NMDA receptor channel is formed by at least two members of the glutamate receptor (GluR) channel subunit families, the GluRε (NR2) and GiuRζ (NR1) sub-unit families3–8. The four ε subunits are distinct in distribution, properties and regulation5–14. On the basis of the Mg2+sensitivity and expression patterns, we have proposed that the εi (NR2A) and ε2 (NR2B) subunits play a role in synaptic plasticity6, 14. Here we show that targeted disruption of the mouse εl subunit gene resulted in significant reduction of the NMDA receptor channel current and long-term potentiation at the hippocampal CA1 synapses. The mutant mice also showed a moderate deficiency in spatial learning. These results support the notion that the NMDA receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning.

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