Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome

Hideki Muramatsu, Hirotoshi Sakaguchi, Takashi Taga, Ken Tabuchi, Souichi Adachi, Masami Inoue, Toshiyuki Kitoh, Aiko Suminoe, Hiromasa Yabe, Eichi Azuma, Yoko Shioda, Atsushi Ogawa, Akitoshi Kinoshita, Hisato Kigasawa, Yuko Osugi, Kazutoshi Koike, Keisei Kawa, Koji Kato, Yoshiko Atsuta, Kazuko Kudo

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a significantly better survival rate than 10 patients transplanted with a conventional conditioning (4 in CR and 6 in non-CR) (3-year EFS (95% confidence interval): 80.0% (20.4-96.9%) vs. 10.0% (0.6%-35.8%), P=0.039). Pediatr Blood Cancer 2014;61:925-927.

本文言語英語
ページ(範囲)925-927
ページ数3
ジャーナルPediatric Blood and Cancer
61
5
DOI
出版ステータス出版済み - 5 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 血液学
  • 腫瘍学

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