Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver

Shinya Iida, Hiroyuki Kamiya, Akihiro Nakaya, Yasuhiro Hayashi, Akihiro Sawada, Noritada Kaji, Yoshinobu Baba, Hideyoshi Harashima

研究成果: Contribution to journalArticle

抄録

Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.

本文言語英語
ページ(範囲)2009-2011
ページ数3
ジャーナルBiological and Pharmaceutical Bulletin
36
12
DOI
出版ステータス出版済み - 12 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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