Reduced stimulatory activity on prostacyclin production by cultured endothelial cells in serum from aged and diabetic patients

F. Umeda, T. Inoguchi, H. Nawata

    研究成果: Contribution to journalArticle査読

    35 被引用数 (Scopus)

    抄録

    Reduced prostacyclin (PGI2) generation by the vascular wall shows a close relationship with the development of atherosclerosis. The present study found plasma-derived serum (PDS) to contain an activity which stimulated PGI2 production by cultured bovine aortic endothelial cells. Diabetic and aged patients with atherosclerotic disease were examined for abnormalities in that stimulatory activity in PDS. PDS obtained from both diabetics (NIDDM) and aged patients showed a significant reduction in the stimulation of PGIZ production by cultured bovine aortic endothelial cells compared with age-matched controls and young healthy volunteers, respectively. It was suggested that the reduced PGI2 stimulatory activity in PDS may be one of the pathogenic mechanisms of vascular lesions such as atherosclerosis in diabetics and aged humans.

    本文言語英語
    ページ(範囲)61-66
    ページ数6
    ジャーナルAtherosclerosis
    75
    1
    DOI
    出版ステータス出版済み - 1 1989

    All Science Journal Classification (ASJC) codes

    • 循環器および心血管医学

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