Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC

Masatake Tanaka, Yuko Masaki, Kosuke Tanaka, Masayuki Miyazaki, Masaki Kato, Rie Sugimoto, Kazuhiko Nakamura, Shinichi Aishima, Ken Shirabe, Makoto Nakamuta, Munechika Enjoji, Kazuhiro Kotoh, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

抄録

The prognosis of patients with hepatocellular carcinoma (HCC) may be improved by novel treatments focusing on the characteristic metabolic changes of this disease. Therefore, we analyzed the biological interactions of metabolic features with the degree of tumor differentiation and the level of malignant potential in 41 patients with completely resectable HCC. The expression levels in resected samples of mRNAs encoded by genes related to tumor metabolism and metastasis were investigated, and the correlation between these expression levels and degrees of differentiation was analyzed. Of the 41 patients, 2 patients had grade I, 27 had grade II, and 12 had grade III tumors. Reductions in the levels of 3-hydroxyacyl-CoA dehydrogenase (HADHA) and acyl-CoA oxidase (ACOX)-2 mRNAs, and increases in pyruvate kinase isoenzyme type M2 (PKM2) mRNA were significantly correlated with the progression of de-differentiation. Analysis of partial correlation coefficients showed that the level of PKM2 mRNA expression was significantly correlated with those of pro-angiogenic genes, vascular endothelial growth factor (VEGF) and ETS-1. Moreover, the levels of VEGF-A and ETS-1 mRNA expression were independently correlated with that of the epithelial-mesenchymal transition (EMT) related gene SNAIL. These findings suggest that reductions in fatty acid oxidation and responses to hypoxia may affect the progression of malignant phenotypes in HCC.

元の言語英語
ページ(範囲)365-370
ページ数6
ジャーナルMolecular medicine reports
7
発行部数2
DOI
出版物ステータス出版済み - 2 1 2013

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Hepatocellular Carcinoma
Fatty Acids
Oxidation
Messenger RNA
Tumors
Pyruvate Kinase
Genes
Vascular Endothelial Growth Factor A
Isoenzymes
3-Hydroxyacyl-CoA Dehydrogenase
Acyl-CoA Oxidase
Neoplasms
Epithelial-Mesenchymal Transition
Metabolic Diseases
Metabolism
Hypoxia
Neoplasm Metastasis
Phenotype
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

これを引用

Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC. / Tanaka, Masatake; Masaki, Yuko; Tanaka, Kosuke; Miyazaki, Masayuki; Kato, Masaki; Sugimoto, Rie; Nakamura, Kazuhiko; Aishima, Shinichi; Shirabe, Ken; Nakamuta, Makoto; Enjoji, Munechika; Kotoh, Kazuhiro; Takayanagi, Ryoichi.

:: Molecular medicine reports, 巻 7, 番号 2, 01.02.2013, p. 365-370.

研究成果: ジャーナルへの寄稿記事

Tanaka, M, Masaki, Y, Tanaka, K, Miyazaki, M, Kato, M, Sugimoto, R, Nakamura, K, Aishima, S, Shirabe, K, Nakamuta, M, Enjoji, M, Kotoh, K & Takayanagi, R 2013, 'Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC', Molecular medicine reports, 巻. 7, 番号 2, pp. 365-370. https://doi.org/10.3892/mmr.2012.1201
Tanaka, Masatake ; Masaki, Yuko ; Tanaka, Kosuke ; Miyazaki, Masayuki ; Kato, Masaki ; Sugimoto, Rie ; Nakamura, Kazuhiko ; Aishima, Shinichi ; Shirabe, Ken ; Nakamuta, Makoto ; Enjoji, Munechika ; Kotoh, Kazuhiro ; Takayanagi, Ryoichi. / Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC. :: Molecular medicine reports. 2013 ; 巻 7, 番号 2. pp. 365-370.
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