Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension

Hongyu Piao, Akihiko Hirata, Hideakira Yokoyama, Takeru Fujii, Ichiro Shimizu, Susumu Ito, Noriho Kamiya, Masahiro Goto

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

This article reports a significant reduction of gastric ulcerogenicity by complex formation of a nonsteroidal anti-inflammatory drug with surfactants. Diclofenac sodium (DFNa) was suspended in medium chain triglyceride (MCT) by forming a complex with an edible lipophilic surfactant. Two types of suspensions, prepared through a membrane emulsification with different pore sizes, were evaluated according to the degree of gastric damage following multiple oral administration in rats. It was shown that gastric ulcerogenicity of DFNa was reduced by the surfactant-drug complexes, at doses up to 12 mg/kg, whereas severe gastric damage was observed upon oral administration of the aqueous solution at doses of 6 mg/kg. Comparable blood levels of DFNa were observed after administration of solution and suspension formulations.

本文言語英語
ページ(範囲)321-325
ページ数5
ジャーナルPharmaceutical Development and Technology
12
3
DOI
出版ステータス出版済み - 5 2007

All Science Journal Classification (ASJC) codes

  • 薬科学

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