Reduction of rewarming injury of the hepatic graft by a heat insulator

S. Wakiyama, K. Yanaga, Y. Soejima, T. Nishizaki, K. Sugimachi

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Background. The deleterious effect of rewarming in orthotopic liver transplantation is recognized. This study examined the significance of rewarming the hepatic allograft, and the possibility of using a heat insulator to reduce rewarming injury. Methods. After total hepatectomy in rats with in situ perfusion by chilled (4°C) lactated Ringer's solution, the livers were divided into four groups of ten each: group 1, 4-h preservation in chilled Ringer's solution and 15 min of rewarming; group 2, 6-h preservation in chilled Ringer's solution; group 3, 6-h preservation in chilled Ringer's solution and 15 min of rewarming; group 4, 6-h preservation in chilled Ringer's solution and 15 min of rewarming with a heat insulator. Glutamic-pyruvic transaminase (GPT) and N-acetyl-β-glucosaminidase (NAG) concentrations in the final graft effluent, and the amount of adenosine 5'-triphosphate (ATP) in liver tissue after preservation, were measured. Results. GPT and NAG concentrations in the final graft effluent of group 3 were higher than those of group 2 (P < 0.01), whereas values in group 4 were lower than those of group 3 (P < 0.05). The final ATP concentration in group 3 was significantly lower than that in group 2 (P < 0.01), whereas the value in group 4 was significantly higher than that of group 3 (P < 0.01). Conclusion. Rewarming diminishes the viability of a liver graft with degradation of ATP, and a heat insulator reduces rewarming injury.

元の言語英語
ページ(範囲)459-463
ページ数5
ジャーナルBritish Journal of Surgery
84
発行部数4
DOI
出版物ステータス出版済み - 1 1 1997

All Science Journal Classification (ASJC) codes

  • Surgery

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    Wakiyama, S., Yanaga, K., Soejima, Y., Nishizaki, T., & Sugimachi, K. (1997). Reduction of rewarming injury of the hepatic graft by a heat insulator. British Journal of Surgery, 84(4), 459-463. https://doi.org/10.1002/bjs.1800840409