Reevaluation of the origin of CD44high "memory phenotype" CD8 T cells: Comparison between memory CD8 T cells and thymus-independent CD8 T cells

Hisakata Yamada, Goro Matsuzaki, Qijie Chen, Yukihide Iwamoto, Kikuo Nomoto

研究成果: ジャーナルへの寄稿学術誌査読

22 被引用数 (Scopus)

抄録

CD44highCD8 T cells in naive mice, which increase with age, and are often referred to as memory CD8 T cells. However, since thymus-independent CD8 T cells have also been shown to be CD44high, the origin of the CD44highCD8 T cells in naive mice remains unclear. In this study, we compared the characteristics of memory CD8 T cells and thymus-independent CD8 T cells in TCR transgenic mice to clarify the origin of the CD44highCD8 T cells in naive normal mice. The memory and thymus-independent CD8 T cells showed differences in surface molecules, spontaneous cell death, cytokine production, and response to IL-2R binding of cytokines. Importantly, the "memory phenotype" CD8 T cells in naive normal mice showed similar characteristics to the thymus-independent CD8 T cells, but differed greatly from "true" memory CD8 T cells in the TCR transgenic mice. Therefore, we conclude that a significant part of the CD44high memory phenotype CD8 T cells in naive normal mice represents thymus-independent CD8 T cells, which may participate in age-related changes in immune responses.

本文言語英語
ページ(範囲)1917-1926
ページ数10
ジャーナルEuropean Journal of Immunology
31
6
DOI
出版ステータス出版済み - 2001

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

フィンガープリント

「Reevaluation of the origin of CD44high "memory phenotype" CD8 T cells: Comparison between memory CD8 T cells and thymus-independent CD8 T cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル