Regeneration of diaphragm with bio-3D cellular patch

Xiu Ying Zhang, Yusuke Yanagi, Zijing Sheng, Kouji Nagata, Koichi Nakayama, Tomoaki Taguchi

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抜粋

Neonates with congenital diaphragmatic hernia often require surgical defect closure with a patch. Alternatives to native diaphragmatic tissue are critically needed for this paediatric surgery. The clinical efficacy of mesh patches is limited by complications associated with residual foreign material and by hernia recurrence. In this study, we used a novel bio-3D printer method to generate large scaffold-free tissue patches composed of human cells. The resulting large tissue constructs had high elasticity and strength. Cellular patches were transplanted into rats with surgically created diaphragmatic defects. Rats survived for over 710 days after implantation of tissue constructs. CT confirmed complete tissue integration of the grafts during rat growth. Histology revealed regeneration of muscle structure, neovascularization, and neuronal networks within the reconstructed diaphragms. Our results demonstrate that created cellular patches are a highly safe and effective therapeutic strategy for repairing diaphragmatic defects, and thus pave the way for a clinical trial.

元の言語英語
ページ(範囲)1-14
ページ数14
ジャーナルBiomaterials
167
DOI
出版物ステータス出版済み - 6 2018

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

これを引用

Zhang, X. Y., Yanagi, Y., Sheng, Z., Nagata, K., Nakayama, K., & Taguchi, T. (2018). Regeneration of diaphragm with bio-3D cellular patch. Biomaterials, 167, 1-14. https://doi.org/10.1016/j.biomaterials.2018.03.012