Region-specific changes in [3H]dizocilpine binding in diazepam- withdrawn rats

Makoto Tsuda, Tsutomu Suzuki, Miwa Misawa

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

In the present study, to clarify the role of the N-methyl-D-aspartate (NMDA) receptor in the appearance of diazepam withdrawal signs, the changes in [3H]dizocilpine binding in several brain regions from diazepam-withdrawn rats were investigated. Brain membranes were prepared 42-45 h after termination of diazepam treatment when maximal withdrawal signs were shown. The B(max) value for [3H]dizocilpine binding was significantly increased in cerebrocortical, but not hippocampal and cerebellar, tissues from diazepam- withdrawn rats, while the K(d) value did not change in any group. Together with our previous finding that NMDA receptor antagonists potently suppress diazepam withdrawal signs, these results suggest that the upregulation of the NMDA receptor in the cerebral cortex may play an important role in the appearance of spontaneous withdrawal signs caused by discontinuation of chronic diazepam treatment.

本文言語英語
ページ(範囲)113-115
ページ数3
ジャーナルNeuroscience Letters
240
2
DOI
出版ステータス出版済み - 1 9 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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