抄録
A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. 1H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.
本文言語 | 英語 |
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ジャーナル | Organic letters |
DOI | |
出版ステータス | 印刷中 - 2021 |
!!!All Science Journal Classification (ASJC) codes
- 生化学
- 物理化学および理論化学
- 有機化学