Regorafenib-induced retinal and gastrointestinal hemorrhage in a metastatic colorectal cancer patient with liver dysfunction

Kenji Tsuchihashi, Hozumi Shimokawa, Kotoe Takayoshi, Kenta Nio, Tomomi Aikawa, Yuzo Matsushita, Iori Wada, Shuji Arita, hiroshi ariyama, Hitoshi Kusaba, Kohei Sonoda, Koichi Akashi, Eishi Baba

研究成果: ジャーナルへの寄稿記事

抄録

Rationale: Regorafenib is effective for metastatic colorectal cancer but its toxicity such as hemorrhage should be considered. The safety of regorafenib for the patient with the liver disease is not known. Patient concerns: Seventy-one-year old man of colon cancer had myodesopsia and blood stool after 14 days from the initiation of regorafenib administration with 50% dose reduction due to liver dysfunction. Diagnoses: Fundus examination revealed hemorrhage of the retinal vein. Interventions: Regorafenib treatment was discontinued and observational therapy was pursued. Outcomes: Retinal and gastrointestinal hemorrhage resolved in 1 week. Lessons: Retinal hemorrhage should be considered as the differential diagnosis of myodesopsia in the patient treated by regorafenib. Safety and pharmacokinetic of continuous regorafenib administration for patients with liver dysfunction remains to be clarified.

元の言語英語
記事番号e8285
ジャーナルMedicine (United States)
96
発行部数42
DOI
出版物ステータス出版済み - 10 1 2017

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Retinal Hemorrhage
Gastrointestinal Hemorrhage
Liver Diseases
Colorectal Neoplasms
Hemorrhage
Retinal Vein
Patient Safety
Colonic Neoplasms
regorafenib
Differential Diagnosis
Pharmacokinetics
Safety
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Regorafenib-induced retinal and gastrointestinal hemorrhage in a metastatic colorectal cancer patient with liver dysfunction. / Tsuchihashi, Kenji; Shimokawa, Hozumi; Takayoshi, Kotoe; Nio, Kenta; Aikawa, Tomomi; Matsushita, Yuzo; Wada, Iori; Arita, Shuji; ariyama, hiroshi; Kusaba, Hitoshi; Sonoda, Kohei; Akashi, Koichi; Baba, Eishi.

:: Medicine (United States), 巻 96, 番号 42, e8285, 01.10.2017.

研究成果: ジャーナルへの寄稿記事

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abstract = "Rationale: Regorafenib is effective for metastatic colorectal cancer but its toxicity such as hemorrhage should be considered. The safety of regorafenib for the patient with the liver disease is not known. Patient concerns: Seventy-one-year old man of colon cancer had myodesopsia and blood stool after 14 days from the initiation of regorafenib administration with 50{\%} dose reduction due to liver dysfunction. Diagnoses: Fundus examination revealed hemorrhage of the retinal vein. Interventions: Regorafenib treatment was discontinued and observational therapy was pursued. Outcomes: Retinal and gastrointestinal hemorrhage resolved in 1 week. Lessons: Retinal hemorrhage should be considered as the differential diagnosis of myodesopsia in the patient treated by regorafenib. Safety and pharmacokinetic of continuous regorafenib administration for patients with liver dysfunction remains to be clarified.",
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AU - Tsuchihashi, Kenji

AU - Shimokawa, Hozumi

AU - Takayoshi, Kotoe

AU - Nio, Kenta

AU - Aikawa, Tomomi

AU - Matsushita, Yuzo

AU - Wada, Iori

AU - Arita, Shuji

AU - ariyama, hiroshi

AU - Kusaba, Hitoshi

AU - Sonoda, Kohei

AU - Akashi, Koichi

AU - Baba, Eishi

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AB - Rationale: Regorafenib is effective for metastatic colorectal cancer but its toxicity such as hemorrhage should be considered. The safety of regorafenib for the patient with the liver disease is not known. Patient concerns: Seventy-one-year old man of colon cancer had myodesopsia and blood stool after 14 days from the initiation of regorafenib administration with 50% dose reduction due to liver dysfunction. Diagnoses: Fundus examination revealed hemorrhage of the retinal vein. Interventions: Regorafenib treatment was discontinued and observational therapy was pursued. Outcomes: Retinal and gastrointestinal hemorrhage resolved in 1 week. Lessons: Retinal hemorrhage should be considered as the differential diagnosis of myodesopsia in the patient treated by regorafenib. Safety and pharmacokinetic of continuous regorafenib administration for patients with liver dysfunction remains to be clarified.

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