Regularizing predicted complexes by mutually exclusive protein-protein interactions

Osamu Maruyama, Limsoon Wong

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

2 被引用数 (Scopus)

抄録

Protein complexes are key entities in the cell responsible for various cellular mechanisms and biological processes. We propose here a method for predicting protein complexes from a protein-protein interaction (PPI) network, using information on mutually exclusive PPIs. If two interactions are mutually exclusive, they are not allowed to exist simultaneously in the same predicted complex. We introduce a new regularization term which checks whether predicted complexes are connected by mutually exclusive PPIs. This regularization term is added into the scoring function of our earlier protein complex prediction tool, PPSampler2. We show that PPSampler2 with mutually exclusive PPIs outperforms the original one. Furthermore, the performance is superior to well-known representative conventional protein complex prediction methods. Thus, it is is effective to use mutual exclusiveness of PPIs in protein complex prediction.

本文言語英語
ホスト出版物のタイトルProceedings of the 2015 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, ASONAM 2015
編集者Jian Pei, Jie Tang, Fabrizio Silvestri
出版社Association for Computing Machinery, Inc
ページ1068-1075
ページ数8
ISBN(電子版)9781450338547
DOI
出版ステータス出版済み - 8 25 2015
イベントIEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, ASONAM 2015 - Paris, フランス
継続期間: 8 25 20158 28 2015

出版物シリーズ

名前Proceedings of the 2015 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, ASONAM 2015

その他

その他IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, ASONAM 2015
Countryフランス
CityParis
Period8/25/158/28/15

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Computer Networks and Communications

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