Regulating DNA replication in bacteria

Kirsten Skarstad, Tsutomu Katayama

研究成果: ジャーナルへの寄稿記事

96 引用 (Scopus)

抄録

The replication origin and the initiator protein DnaA are the main targets for regulation of chromosome replication in bacteria. The origin bears multiple DnaA binding sites, while DnaA contains ATP/ADP-binding and DNA-binding domains. When enough ATP-DnaA has accumulated in the cell, an active initiation complex can be formed at the origin resulting in strand opening and recruitment of the replicative helicase. In Escherichia coli, oriC activity is directly regulated by DNA methylation and specific oriC-binding proteins. DnaA activity is regulated by proteins that stimulate ATP-DnaA hydrolysis, yielding inactive ADP-DnaA in a replication-coupled negative-feedback manner, and by DnaA-binding DNA elements that control the subcellular localization of DnaA or stimulate the ADP-to-ATP exchange of the DnaA-bound nucleotide. Regulation of dnaA gene expression is also important for initiation. The principle of replication-coupled negative regulation of DnaA found in E. coli is conserved in eukaryotes as well as in bacteria. Regulations by oriC-binding proteins and dnaA gene expression are also conserved in bacteria.

元の言語英語
ページ(範囲)1-17
ページ数17
ジャーナルCold Spring Harbor Perspectives in Biology
5
発行部数4
DOI
出版物ステータス出版済み - 4 1 2013

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DNA Replication
Bacteria
Adenosine Triphosphate
Adenosine Diphosphate
DNA
Gene expression
Escherichia coli
Carrier Proteins
Replication Origin
Gene Expression Regulation
DNA Methylation
Chromosomes
Eukaryota
Hydrolysis
Proteins
Nucleotides
Binding Sites
Feedback
Gene Expression

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Regulating DNA replication in bacteria. / Skarstad, Kirsten; Katayama, Tsutomu.

:: Cold Spring Harbor Perspectives in Biology, 巻 5, 番号 4, 01.04.2013, p. 1-17.

研究成果: ジャーナルへの寄稿記事

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