Regulation of cardiovascular TRP channel functions along the NO-cGMP-PKG axis

Ryuji Inoue, Juan Shi, Zhong Jian, Yuko Imai

研究成果: Contribution to journalReview article査読

4 被引用数 (Scopus)

抄録

There is growing body of evidence that nitric oxide (NO)-cGMP-PKG signaling plays a central role in negative regulation of cardiovascular (CV) responses and its disorders through suppressed Ca2+ dynamics. Other lines of evidence also reveal the stimulatory effects of this signaling on some CV functions. Recently, transient receptor potential (TRP) channels have received much attention as non-voltage-gated Ca2+ channels involved in CV physiology and pathophysiology. Available information suggests that these channels undergo both inhibition and activation by NO via PKG-mediated phosphorylation and S-nitrosylation, respectively, and also act as upstream regulators to promote endothelial NO production. This review summarizes the roles of NO-cGMP-PKG signaling pathway, particularly in regulating TRP channel functions with their associated physiology and pathophysiology.

本文言語英語
ページ(範囲)347-360
ページ数14
ジャーナルExpert Review of Clinical Pharmacology
3
3
DOI
出版ステータス出版済み - 5 2010

All Science Journal Classification (ASJC) codes

  • 薬理学、毒性学および薬学(全般)
  • 薬理学(医学)

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