Regulation of cell proliferation and tumorigenesis by ubiquitin-proteasome pathway

研究成果: ジャーナルへの寄稿評論記事

抄録

The strict regulation of protein degradation by the ubiquitin-proteasome pathway is pivotal for cell cycle progression. Skp2 and Fbw7 are F-box proteins that are substrate-recognition subunits of the SCF-type ubiquitin ligase complex and involved in cell cycle entry and exit. Skp2 promotes the degradation of negative regulators of the cell cycle, such as p27, and facilitates the cell cycle entry. On the other hand, Fbw7 promotes the degradation of positive regulators of the cell cycle, such as c-Myc, and induces the cell cycle exit. We have demonstrated the in vivo roles of Skp2 and Fbw7 in cell cycle regulation using gene-targeting technology in mice. Consistent with our animal models, clinical studies have suggested Skp2 as an oncogene and Fbw7 as an oncosuppressor gene. These accumulating lines of evidence support the notion that Skp2 and Fbw7 are involved in cell cycle regulation and tumorigenesis.

元の言語英語
ページ(範囲)363-370
ページ数8
ジャーナルBiotherapy
22
発行部数6
出版物ステータス出版済み - 11 1 2008

Fingerprint

Proteasome Endopeptidase Complex
Ubiquitin
Cell Cycle
Carcinogenesis
Cell Proliferation
SKP Cullin F-Box Protein Ligases
F-Box Proteins
Gene Targeting
Oncogenes
Proteolysis
Animal Models
Technology
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Regulation of cell proliferation and tumorigenesis by ubiquitin-proteasome pathway. / Matsumoto, Akinobu; Nakayama, Keiichi.

:: Biotherapy, 巻 22, 番号 6, 01.11.2008, p. 363-370.

研究成果: ジャーナルへの寄稿評論記事

@article{c9f17dfdefa0436d88ad7ead6c016993,
title = "Regulation of cell proliferation and tumorigenesis by ubiquitin-proteasome pathway",
abstract = "The strict regulation of protein degradation by the ubiquitin-proteasome pathway is pivotal for cell cycle progression. Skp2 and Fbw7 are F-box proteins that are substrate-recognition subunits of the SCF-type ubiquitin ligase complex and involved in cell cycle entry and exit. Skp2 promotes the degradation of negative regulators of the cell cycle, such as p27, and facilitates the cell cycle entry. On the other hand, Fbw7 promotes the degradation of positive regulators of the cell cycle, such as c-Myc, and induces the cell cycle exit. We have demonstrated the in vivo roles of Skp2 and Fbw7 in cell cycle regulation using gene-targeting technology in mice. Consistent with our animal models, clinical studies have suggested Skp2 as an oncogene and Fbw7 as an oncosuppressor gene. These accumulating lines of evidence support the notion that Skp2 and Fbw7 are involved in cell cycle regulation and tumorigenesis.",
author = "Akinobu Matsumoto and Keiichi Nakayama",
year = "2008",
month = "11",
day = "1",
language = "English",
volume = "22",
pages = "363--370",
journal = "Biotherapy",
issn = "0914-2223",
number = "6",

}

TY - JOUR

T1 - Regulation of cell proliferation and tumorigenesis by ubiquitin-proteasome pathway

AU - Matsumoto, Akinobu

AU - Nakayama, Keiichi

PY - 2008/11/1

Y1 - 2008/11/1

N2 - The strict regulation of protein degradation by the ubiquitin-proteasome pathway is pivotal for cell cycle progression. Skp2 and Fbw7 are F-box proteins that are substrate-recognition subunits of the SCF-type ubiquitin ligase complex and involved in cell cycle entry and exit. Skp2 promotes the degradation of negative regulators of the cell cycle, such as p27, and facilitates the cell cycle entry. On the other hand, Fbw7 promotes the degradation of positive regulators of the cell cycle, such as c-Myc, and induces the cell cycle exit. We have demonstrated the in vivo roles of Skp2 and Fbw7 in cell cycle regulation using gene-targeting technology in mice. Consistent with our animal models, clinical studies have suggested Skp2 as an oncogene and Fbw7 as an oncosuppressor gene. These accumulating lines of evidence support the notion that Skp2 and Fbw7 are involved in cell cycle regulation and tumorigenesis.

AB - The strict regulation of protein degradation by the ubiquitin-proteasome pathway is pivotal for cell cycle progression. Skp2 and Fbw7 are F-box proteins that are substrate-recognition subunits of the SCF-type ubiquitin ligase complex and involved in cell cycle entry and exit. Skp2 promotes the degradation of negative regulators of the cell cycle, such as p27, and facilitates the cell cycle entry. On the other hand, Fbw7 promotes the degradation of positive regulators of the cell cycle, such as c-Myc, and induces the cell cycle exit. We have demonstrated the in vivo roles of Skp2 and Fbw7 in cell cycle regulation using gene-targeting technology in mice. Consistent with our animal models, clinical studies have suggested Skp2 as an oncogene and Fbw7 as an oncosuppressor gene. These accumulating lines of evidence support the notion that Skp2 and Fbw7 are involved in cell cycle regulation and tumorigenesis.

UR - http://www.scopus.com/inward/record.url?scp=57849169397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57849169397&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:57849169397

VL - 22

SP - 363

EP - 370

JO - Biotherapy

JF - Biotherapy

SN - 0914-2223

IS - 6

ER -