Regulation of GABAA-receptor surface expression with special reference to the involvement of GABARAP (GABAA receptor-associated protein) and PRIP (phospholipase C-related, but catalytically inactive protein)

Takashi Kanematsu, Akiko Mizokami, Keiko Watanabe, Masato Hirata

研究成果: ジャーナルへの寄稿総説査読

37 被引用数 (Scopus)

抄録

GABAA receptors are heteropentameric ligand-gated chloride channels composed of a variety of subunits, including α1 - 6, β1 - 3, γ1 - 3, δ, ε, θ, and π, and play a key role in controlling inhibitory neuronal activity. Modification of the efficacy of the synaptic strength is produced by changes in both the number of neuronal surface receptors and pentameric molecular assembly, leading to differences of sensitivity to neurotransmitters and neuromimetic drugs. Therefore, it is important to understand the molecular mechanisms regulating the so-called "life cycle of GABAA receptors" including sequential pentameric assembly at the site synthesized, intracellular transport through the Golgi apparatus and the cytoplasm, insertion into the cell membrane, functional modulation at the cell surface, and finally internalization, followed by either recycling back to the surface membrane or lysosomal degradation. This review is focused on events related to the surface expression of the receptor containing the γ2 subunit and clathrin /AP2 complex-mediated phospho-regulated endocytosis of the receptor, with special reference to the function of novel GABAA receptor modulators, GABARAP (GABAA receptor-associated protein) and PRIP (phospholipase C-related, but catalytically inactive protein).

本文言語英語
ページ(範囲)285-292
ページ数8
ジャーナルJournal of Pharmacological Sciences
104
4
DOI
出版ステータス出版済み - 2007

!!!All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

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