TY - JOUR
T1 - Regulation of hematopoietic development by ZBTB transcription factors
AU - Maeda, Takahiro
N1 - Funding Information:
of the Maeda lab for their contributions to the work reviewed here. I also thank Elise Lamar for critical reading of the manuscript. This work was supported by American Cancer Society (RSG-13-379-01-LIB), NIH (R56 DK105001) and an American Society of Hematology Bridge Grant Program to T.M.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Hematopoietic development is governed by the coordinated expression of lineage- and differentiation stage-specific genes. Transcription factors play major roles in this process and their perturbation may underlie hematologic and immunologic disorders. Nearly 1900 transcription factors are encoded in the human genome: of these, 49 BTB (for broad-complex, tram-track and bric à brac)-zinc finger transcription factors referred to as ZBTB or POK proteins have been identified. ZBTB proteins, including BCL6, PLZF, ThPOK and LRF, exhibit a broad spectrum of functions in normal and malignant hematopoiesis. This review summarizes developmental and molecular functions of ZBTB proteins relevant to hematology.
AB - Hematopoietic development is governed by the coordinated expression of lineage- and differentiation stage-specific genes. Transcription factors play major roles in this process and their perturbation may underlie hematologic and immunologic disorders. Nearly 1900 transcription factors are encoded in the human genome: of these, 49 BTB (for broad-complex, tram-track and bric à brac)-zinc finger transcription factors referred to as ZBTB or POK proteins have been identified. ZBTB proteins, including BCL6, PLZF, ThPOK and LRF, exhibit a broad spectrum of functions in normal and malignant hematopoiesis. This review summarizes developmental and molecular functions of ZBTB proteins relevant to hematology.
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U2 - 10.1007/s12185-016-2035-x
DO - 10.1007/s12185-016-2035-x
M3 - Review article
C2 - 27250345
AN - SCOPUS:84973138184
SN - 0925-5710
VL - 104
SP - 310
EP - 323
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 3
ER -