Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier

Khadijah Zai, Narumi Ishihara, Hiroyuki Oguchi, Masato Hirota, Akihiro Kishimura, Takeshi Mori, Koji Hase, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

抄録

Immunomodulatory function of all-trans retinoic acid (ATRA) has been gathering much attention for the therapy of autoimmune diseases. ATRA is a chemically unstable molecule which requires proper formulation for targeted delivery. Here we examined nanostructured lipid carrier (NLC) for the formulation of ATRA. NLC is a representative nanoparticle formulation especially suited for oral delivery. We established the preparation procedures of ATRA-containing NLC (NLC-RA) which minimizes the degradation of ATRA during the preparation process. NLC-RA thus obtained was taken up by macrophages and induced anti-inflammatory response via suppressing NF-κB signaling as well as via enhancing the production of anti-inflammatory cytokines. Moreover, NLC-RA enhanced differentiation of naïve T cells to regulatory T cells in the co-culture system with dendritic cells. These results suggest that NLC-RA is a promising alternative therapy for the autoimmune diseases especially intestinal bowel disease. (Figure presented.).

元の言語英語
ページ(範囲)1-11
ページ数11
ジャーナルJournal of Biomaterials Science, Polymer Edition
30
発行部数1
DOI
出版物ステータス出版済み - 1 2 2019

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T-cells
Macrophages
Regulatory T-Lymphocytes
Tretinoin
Lipids
Acids
Autoimmune Diseases
Anti-Inflammatory Agents
Intestinal Diseases
Complementary Therapies
Coculture Techniques
Cell culture
Nanoparticles
Dendritic Cells
Cytokines
T-Lymphocytes
Degradation
Molecules

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

これを引用

Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier. / Zai, Khadijah; Ishihara, Narumi; Oguchi, Hiroyuki; Hirota, Masato; Kishimura, Akihiro; Mori, Takeshi; Hase, Koji; Katayama, Yoshiki.

:: Journal of Biomaterials Science, Polymer Edition, 巻 30, 番号 1, 02.01.2019, p. 1-11.

研究成果: ジャーナルへの寄稿記事

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AU - Hirota, Masato

AU - Kishimura, Akihiro

AU - Mori, Takeshi

AU - Hase, Koji

AU - Katayama, Yoshiki

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